Immune mechanisms of acute and chronic rejection

被引:31
作者
Becker, Luis Eduardo [1 ]
Morath, Christian [1 ]
Suesal, Caner [2 ]
机构
[1] Heidelberg Univ, Div Nephrol, Neuenheimer Feld 162, D-69120 Heidelberg, Germany
[2] Heidelberg Univ, Dept Transplantat Immunol, Neuenheimer Feld 305, D-69120 Heidelberg, Germany
关键词
Antibody; HLA; Kidney transplantation; De novo DSA; Rejection; ANTIBODY-MEDIATED REJECTION; KIDNEY-TRANSPLANT FAILURE; DONOR-SPECIFIC ANTIBODIES; HLA ANTIBODIES; GRAFT LOSS; ALLOGRAFT SURVIVAL; RENAL-ALLOGRAFTS; POSTTRANSPLANT; ANTIGENS; RECIPIENTS;
D O I
10.1016/j.clinbiochem.2016.02.001
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
With the currently available immunosuppression, severe T-cell mediated rejection has become a rare event. With the introduction of modern antibody-detection techniques, such as the L-SAB technology, acute or hyperacute antibody-mediated rejection of the kidney are also seen infrequently. In contrast, chronic antibody-mediated rejection is considered to be a major contributor to graft loss in the late posttransplant phase. Problems in the management of chronic antibody-mediated rejection are effective prevention of the development of alloantibodies against donor HLA and the early identification of patients at risk for this entity. Finally, today there is still no-effective strategy to treat this indolent and slowly progressing form of antibody-mediated rejection. Herein, we review the pathomechanisms of the different forms of rejection and the clinical significance of these entities in human kidney transplantation. (C) 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:320 / 323
页数:4
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