Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers

被引：27

作者：

Li, Zhen Ying

Liu, Zhao Sheng

Zhang, Qing Wei

Duan, Hong Quan ^{[1
]}

机构：

[1] Tianjin Med Univ, Sch Pharmaceut Sci, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Basic Med Res Ctr Tianjin, Tianjin 300070, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

molecularly imprinted polymer; monolithic column; naproxen; chiral separation;

D O I：

10.1016/j.cclet.2007.01.037

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Molecularly imprinted polymers (MIPs), using (S)-naproxen as template and the combination of butyl methacrylate (BMA) and MAA (1:1 molar ratio) as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen (Rs = 1.55) and column efficiencies of imprinted molecules (N = 2860 plates/m) than that with pure MAA. (c) 2007 Hong Quan Duan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

收藏

页码：322 / 324

页数：3

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