Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy

被引：60
作者：
Rolfe, Alan
Samarakoon, Thiwanka B.
Hanson, Paul R. [1 ]
机构：
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 06期
关键词：
2-SUBSTITUTED 3,4-DIHYDRO-2H-1,4-BENZOXAZINES; CYCLIZATION REACTION; HIGH-LOAD; MICHAEL; COMPLEXES; VERSATILE; REAGENT;
D O I：
10.1021/ol100035e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1'-dioxides and oxathiazepine-1,1'-dioxides. This protocol combines an epoxide ring-opening with either an SNAr or oxa-Michael cyclization pathway.
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页码：1216 / 1219
页数：4
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