Antiischemic effects of estrogens

被引：0

作者：

Auer J. ^{[1
]}

Berent R. ^{[1
]}

Mayr H. ^{[1
]}

Kirchgatterer A. ^{[1
]}

Eber B. ^{[1
]}

机构：

[1] II. Interne Abteilung/Kardiologie, Allg. Krankenhaus der Barmh. Schwestern vom Hl. Kreuz, A-4600 Wels, Österreich

来源：

Zeitschrift für Kardiologie | 2000年 / 89卷 / 5期

关键词：

Coronary heart disease; Estrogens; Hormone replacement therapy; Myocardial ischemia;

D O I：

10.1007/s003920050509

中图分类号：

学科分类号：

摘要：

Consideration of estrogen replacement therapy is well established in the treatment of postmenopausal syndrome and osteoporosis in menopause. Some observational epidemiologic studies on this topic have suggested beneficial effects on cardiovascular disease. A prospective, controlled, randomized clinical trial with respect to cardiovascular events and mortality in postmenopausal hormone users, the HERS (Heart and Estrogen/Progestin Replacement) study has recently been published. Antiischemic effects of estrogens are mediated by improvement of menopausal-associated endothelial dysfunction, calcium antagonism, and activation of endothelial synthesis of prostacyclin. Improvement in functional state and reduction of stress-induced myocardial ischemia with hormone replacement therapy (HRT) have been demonstrated in several clinical trials. Thus, because of available clinical data, introduction of HRT for cardiovascular reasons in patients with coronary artery disease is still considered ambigous and cannot be generally recommended for secondary prevention in this group of patients.

引用

页码：434 / 441

页数：7