Systemic Mastocytosis Treatment with Midostaurin: [18F]FDG PET/CT as a Potential Monitoring Tool for Therapy Outcome

被引：0
作者：
Burgard, Caroline [1 ]
Rosar, Florian [1 ]
Khreish, Fadi [1 ]
Ezziddin, Samer [1 ]
机构：
[1] Saarland Univ, Dept Nucl Med, D-66421 Homburg, Germany
来源：
DIAGNOSTICS | 2022年 / 12卷 / 03期
关键词：
systemic mastocytosis; FDG PET/CT; midostaurin; tyrosine kinase inhibitor; therapy outcome; MAST-CELL DISORDERS; EFFICACY; MUTATION; SAFETY;
D O I：
10.3390/diagnostics12030680
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report the case of a 68-year-old patient with diagnosed systemic mastocytosis and histopathologically confirmed manifestations in the stomach and intestinal tract who underwent F-18-Fluorodeoxyglucose ([F-18]FDG) positron-emission tomography/computed tomography (PET/CT) pre- and post-6-month therapy with midostaurin, an established tyrosine kinase inhibitor. Post-therapeutic [F-18]FDG PET/CT showed decreased multifocal tracer uptake in the known lesions in the gastrointestinal tract, which was consistent with relief of the patient's symptoms and decrease in serum tryptase level. [F-18]FDG PET/CT may thus be considered a potential method for monitoring the outcome of midostaurin therapy in systemic mastocytosis.
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