Toll-like receptors in the induction of the innate immune response

被引：2507

作者：

Aderem, A ^{[1
]}

Ulevitch, RJ

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

NATURE | 2000年 / 406卷 / 6797期

关键词：

D O I：

10.1038/35021228

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.

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收藏

页码：782 / 787

页数：6

相关论文

共 59 条

[21] Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide [J].

Kirschning, CJ ;

Wesche, H ;

Ayres, TM ;

Rothe, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (11) :2091-2097

[22] ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway [J].

Kopp, E ;

Medzhitov, R ;

Carothers, J ;

Xiao, CC ;

Douglas, I ;

Janeway, CA ;

Ghosh, S .

GENES & DEVELOPMENT, 1999, 13 (16) :2059-2071

[23] The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults [J].

Lemaitre, B ;

Nicolas, E ;

Michaut, L ;

Reichhart, JM ;

Hoffmann, JA .

CELL, 1996, 86 (06) :973-983

[24] Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila [J].

Levashina, EA ;

Langley, E ;

Green, C ;

Gubb, D ;

Ashburner, M ;

Hoffmann, JA ;

Reichhart, JM .

SCIENCE, 1999, 285 (5435) :1917-1919

[25] Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide [J].

Lien, E ;

Means, TK ;

Heine, H ;

Yoshimura, A ;

Kusumoto, S ;

Fukase, K ;

Fenton, MJ ;

Oikawa, M ;

Qureshi, N ;

Monks, B ;

Finberg, RW ;

Ingalls, RR ;

Golenbock, DT .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (04) :497-504

[26] Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products [J].

Lien, E ;

Sellati, TJ ;

Yoshimura, A ;

Flo, TH ;

Rawadi, G ;

Finberg, RW ;

Carroll, JD ;

Espevik, T ;

Ingalls, RR ;

Radolf, JD ;

Golenbock, DT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (47) :33419-33425

[27] TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling [J].

Lomaga, MA ;

Yeh, WC ;

Sarosi, I ;

Duncan, GS ;

Furlonger, C ;

Ho, A ;

Morony, S ;

Capparelli, C ;

Van, G ;

Kaufman, S ;

van der Heiden, A ;

Itie, A ;

Wakeham, A ;

Khoo, W ;

Sasaki, T ;

Cao, ZD ;

Penninger, JM ;

Paige, CJ ;

Lacey, DL ;

Dunstan, CR ;

Boyle, WJ ;

Goeddel, DV ;

Mak, TW .

GENES & DEVELOPMENT, 1999, 13 (08) :1015-1024

[28]

Means TK, 1999, J IMMUNOL, V163, P3920

[29]

Means TK, 1999, J IMMUNOL, V163, P6748

[30] A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [J].

Medzhitov, R ;

PrestonHurlburt, P ;

Janeway, CA .

NATURE, 1997, 388 (6640) :394-397

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