Lipidomic insight into cardiovascular diseases

被引：50

作者：

Kohno, Shohei ^{[1
]}

Keenan, Audrey L. ^{[1
]}

Ntambi, James M. ^{[2
,3
]}

Miyazaki, Makoto ^{[1
]}

机构：

[1] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO 80045 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Nutr Sci, 1415 Linden Dr, Madison, WI 53706 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 504卷 / 03期

关键词：

Lipidomics; Metabolomics; Lipid metabolism; Cardiovascular disease; CORONARY-ARTERY-DISEASE; VASCULAR CALCIFICATION; MASS-SPECTROMETRY; RISK-FACTORS; FATTY-ACIDS; PLASMA; LIPOPROTEINS; METABOLITE; EVENTS;

D O I：

10.1016/j.bbrc.2018.04.106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular disease is a primary cause of mortality worldwide. Therefore, it is of major interest to identify sensitive molecular markers that predict cardiovascular events and point to therapeutic strategies that will increase lifespans. Dysregulated lipid metabolism is recognized as an established risk factor in cardiovascular diseases. However, it is still largely unknown which specific lipid molecular species reflect cardiovascular risk. In addition, understanding the whole lipidome signature in vascular pathophysiology is challenging. Recent advancements of mass-spectrometry allow researchers to detect each individual lipid species from unbiased small samples. In this review, we update the current research on lipidomic approaches in cardiovascular diseases. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：590 / 595

页数：6

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