RAS and connective tissue in the heart

被引：32
作者：
Sun, Y [1 ]
Weber, KT [1 ]
机构：
[1] Univ Tennessee, Ctr Hlth Sci, Dept Med, Div Cardiovasc Dis,Dobbs Res Inst, Memphis, TN 38163 USA
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2003年 / 35卷 / 06期
关键词：
angiotensin receptors; renin; angiotensin converting enzyme; infarct scar; myocardial infarction;
D O I：
10.1016/S1357-2725(02)00276-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Circulating angiotensin (Ang) II has well-known endocrine properties in the cardiovasculature. AngII, produced de novo within the heart, has various autocrine and paracrine properties on resident cells expressed via AT(1) receptor-ligand binding. Herein, we review the heart's renin-angiotensin system and its role in connective tissue turnover involving heart valve leaflets and fibrous tissue that appears at sites of injury, such as following myocardial infarction. (C) 2003 Elsevier Science Ltd All rights reserved.
引用
收藏
页码：919 / 931
页数：13
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