Synthesis and biological action of novel 4-position-modified derivatives of D-myo-Inositol 1,4,5-trisphosphate

被引：17
作者：
Bello, Davide
Aslam, Tashfeen
Bultynck, Geert
Slawin, Alexandra M. Z.
Roderick, H. Llewelyn
Bootman, Martin D.
Conway, Stuart J. [1 ]
机构：
[1] Univ St Andrews, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland
[2] Univ St Andrews, Sch Chem, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[3] Katholieke Univ Leuven, Mol Signalling Lab, B-3000 Louvain, Belgium
[4] Babraham Inst, Mol Signalling Lab, Cambridge CB22 3AT, England
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 15期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1021/jo070611a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.
引用
收藏
页码：5647 / 5659
页数：13
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