Genomics - Guilt by association

被引:33
作者
Bowcock, Anne M.
机构
[1] Washington Univ, Sch Med, Dept Genet, Div Human Genet, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pediat, Div Human Genet, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Med, Div Human Genet, St Louis, MO 63110 USA
关键词
D O I
10.1038/447645a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In a tour-de-force demonstration of feasibility, a consortium of 50 research teams uses 500,000 genetic markers from each of 17,000 individuals to identify 24 genetic risk factors for 7 common human diseases.
引用
收藏
页码:645 / 646
页数:2
相关论文
共 14 条
[1]   A haplotype map of the human genome [J].
Altshuler, D ;
Brooks, LD ;
Chakravarti, A ;
Collins, FS ;
Daly, MJ ;
Donnelly, P ;
Gibbs, RA ;
Belmont, JW ;
Boudreau, A ;
Leal, SM ;
Hardenbol, P ;
Pasternak, S ;
Wheeler, DA ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Zeng, CQ ;
Gao, Y ;
Hu, HR ;
Hu, WT ;
Li, CH ;
Lin, W ;
Liu, SQ ;
Pan, H ;
Tang, XL ;
Wang, J ;
Wang, W ;
Yu, J ;
Zhang, B ;
Zhang, QR ;
Zhao, HB ;
Zhao, H ;
Zhou, J ;
Gabriel, SB ;
Barry, R ;
Blumenstiel, B ;
Camargo, A ;
Defelice, M ;
Faggart, M ;
Goyette, M ;
Gupta, S ;
Moore, J ;
Nguyen, H ;
Onofrio, RC ;
Parkin, M ;
Roy, J ;
Stahl, E ;
Winchester, E ;
Ziaugra, L ;
Shen, Y .
NATURE, 2005, 437 (7063) :1299-1320
[2]  
BUCKWALTER JA, 1957, SURG GYNECOL OBSTET, V104, P176
[3]   Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].
Burton, Paul R. ;
Clayton, David G. ;
Cardon, Lon R. ;
Craddock, Nick ;
Deloukas, Panos ;
Duncanson, Audrey ;
Kwiatkowski, Dominic P. ;
McCarthy, Mark I. ;
Ouwehand, Willem H. ;
Samani, Nilesh J. ;
Todd, John A. ;
Donnelly, Peter ;
Barrett, Jeffrey C. ;
Davison, Dan ;
Easton, Doug ;
Evans, David ;
Leung, Hin-Tak ;
Marchini, Jonathan L. ;
Morris, Andrew P. ;
Spencer, Chris C. A. ;
Tobin, Martin D. ;
Attwood, Antony P. ;
Boorman, James P. ;
Cant, Barbara ;
Everson, Ursula ;
Hussey, Judith M. ;
Jolley, Jennifer D. ;
Knight, Alexandra S. ;
Koch, Kerstin ;
Meech, Elizabeth ;
Nutland, Sarah ;
Prowse, Christopher V. ;
Stevens, Helen E. ;
Taylor, Niall C. ;
Walters, Graham R. ;
Walker, Neil M. ;
Watkins, Nicholas A. ;
Winzer, Thilo ;
Jones, Richard W. ;
McArdle, Wendy L. ;
Ring, Susan M. ;
Strachan, David P. ;
Pembrey, Marcus ;
Breen, Gerome ;
St Clair, David ;
Caesar, Sian ;
Gordon-Smith, Katherine ;
Jones, Lisa ;
Fraser, Christine ;
Green, Elain K. .
NATURE, 2007, 447 (7145) :661-678
[4]   Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium [J].
Carlson, CS ;
Eberle, MA ;
Rieder, MJ ;
Yi, Q ;
Kruglyak, L ;
Nickerson, DA .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 74 (01) :106-120
[5]  
CAVALLISFORZA LL, 1973, AM J HUM GENET, V25, P82
[6]   Identification of a variant associated with adult-type hypolactasia [J].
Enattah, NS ;
Sahi, T ;
Savilahti, E ;
Terwilliger, JD ;
Peltonen, L ;
Järvelä, I .
NATURE GENETICS, 2002, 30 (02) :233-237
[7]  
FRAYLING TM, 2007, SCIENCE
[8]   A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 [J].
Hampe, Jochen ;
Franke, Andre ;
Rosenstiel, Philip ;
Till, Andreas ;
Teuber, Markus ;
Huse, Klaus ;
Albrecht, Mario ;
Mayr, Gabriele ;
De La Vega, Francisco M. ;
Briggs, Jason ;
Guenther, Simone ;
Prescott, Natalie J. ;
Onnie, Clive M. ;
Haesler, Robert ;
Sipos, Bence ;
Foelsch, Ulrich R. ;
Lengauer, Thomas ;
Platzer, Matthias ;
Mathew, Christopher G. ;
Krawczak, Michael ;
Schreiber, Stefan .
NATURE GENETICS, 2007, 39 (02) :207-211
[9]  
PARKES M, 2007, NATURE GENET, DOI DOI 10.1038/NG2061
[10]   Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis [J].
Rioux, John D. ;
Xavier, Ramnik J. ;
Taylor, Kent D. ;
Silverberg, Mark S. ;
Goyette, Philippe ;
Huett, Alan ;
Green, Todd ;
Kuballa, Petric ;
Barmada, M. Michael ;
Datta, Lisa Wu ;
Shugart, Yin Yao ;
Griffiths, Anne M. ;
Targan, Stephan R. ;
Ippoliti, Andrew F. ;
Bernard, Edmond-Jean ;
Mei, Ling ;
Nicolae, Dan L. ;
Regueiro, Miguel ;
Schumm, L. Philip ;
Steinhart, A. Hillary ;
Rotter, Jerome I. ;
Duerr, Richard H. ;
Cho, Judy H. ;
Daly, Mark J. ;
Brant, Steven R. .
NATURE GENETICS, 2007, 39 (05) :596-604