Herpes simplex virus encephalitis in Peru: a multicentre prospective study

被引：5

作者：

Montano, S. M. ^{[1
]}

Mori, N. ^{[2
,3
]}

Nelson, C. A. ^{[2
]}

Ton, T. G. N. ^{[4
]}

Celis, V. ^{[5
]}

Ticona, E. ^{[6
,7
]}

Sihuincha, M. ^{[8
]}

Tilley, D. H. ^{[1
]}

Kochel, T. ^{[1
]}

Zunt, J. R. ^{[4
,9
,10
]}

机构：

[1] US Naval Med Res Unit 6, Callao, Peru

[2] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA

[3] Hosp Daniel Alcides Carrion, Callao, Peru

[4] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA

[5] Hosp Belen, Trujillo, Peru

[6] Hosp Mayo, Lima, Peru

[7] Univ Nacl Mayor San Marcos, Lima 14, Peru

[8] Hosp Cesar Garayar Garcia, Loreto, Peru

[9] Univ Washington, Sch Med, Dept Global Hlth, Seattle, WA USA

[10] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

来源：

EPIDEMIOLOGY AND INFECTION | 2016年 / 144卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Central nervous system infections; encephalitis; epidemiology; herpes simplex virus; virology; INFECTIONS; ETIOLOGIES; DIAGNOSIS; ADULTS;

D O I：

10.1017/S0950268815003222

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Herpes simplex virus (HSV) is one of the most commonly identified infectious aetiologies of encephalitis in North America and Europe. The epidemiology of encephalitis beyond these regions, however, is poorly defined. During 2009-2012 we enrolled 313 patients in a multicentre prospective study of encephalitis in Peru, 45 (14.4%) of whom had confirmed HSV infection. Of 38 patients with known HSV type, 84% had HSV-1 and 16% had HSV-2. Patients with HSV infection were significantly more likely to present in the summer months (44.4% vs. 20.0%, P = 0.003) and have nausea (60.0% vs. 39.8%, P = 0.01) and rash (15.6% vs. 5.3%, P = 0.01) compared to patients without HSV infection. These findings highlight differences in the epidemiology and clinical presentation of HSV encephalitis outside of the Northern Hemisphere that warrant further investigation. Furthermore, there is an urgent need for improved HSV diagnostic capacity and availability of intravenous acyclovir in Peru.

引用

页码：1673 / 1678

页数：6

共 22 条

[1]

Aydemir O, 2007, CLIN OPHTHALMOL, V1, P127

[2] Detection of Herpesvirus, Enterovirus, and Arbovirus Infection in Patients With Suspected Central Nervous System Viral Infection in the Western Brazilian Amazon [J].