The control of kainic acid-induced status epilepticus

被引：23

作者：

Vermoesen, Katia ^{[1
]}

Smolders, Ilse ^{[1
]}

Massie, Ann ^{[1
]}

Michotte, Yvette ^{[1
]}

Clinckers, Ralph ^{[1
]}

机构：

[1] Vrije Univ Brussel, Res Grp Expt Pharmacol, Dept Pharmaceut Chem & Drug Anal, B-1090 Brussels, Belgium

来源：

EPILEPSY RESEARCH | 2010年 / 90卷 / 1-2期

关键词：

Status epilepticus; Kainic acid; Diazepam; Ketamine; Rat; ANTIEPILEPTIC DRUGS; KAINATE; MODEL;

D O I：

10.1016/j.eplepsyres.2010.04.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the present study the effectiveness of different diazepam ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is only behaviourally assessed. Diazepam and ketamine synergistically blocked all electrographical seizure activity. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：164 / 166

页数：3

共 8 条

[1] Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus [J].

Bankstahl, Jens P. ;

Loescher, Wolfgang .

EPILEPSY RESEARCH, 2008, 82 (01) :70-85

[2] N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy [J].

Brandt, C ;

Potschka, H ;

Löscher, W ;

Ebert, U .

NEUROSCIENCE, 2003, 118 (03) :727-740

[3] Effective treatments of prolonged status epilepticus in developing rats [J].

Hasson, Henry ;

Kim, Mimi ;

Moshe, Solomon L. .

EPILEPSY & BEHAVIOR, 2008, 13 (01) :62-69

[4] Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy [J].

Hellier, JL ;

Patrylo, PR ;

Buckmaster, PS ;

Dudek, FE .

EPILEPSY RESEARCH, 1998, 31 (01) :73-84

[5] A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation [J].

Martin, Brandon S. ;

Kapur, Jaideep .

EPILEPSIA, 2008, 49 (02) :248-255

[6] Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus [J].

Mazarati, AM ;

Baldwin, RA ;

Sankar, R ;

Wasterlain, CG .

BRAIN RESEARCH, 1998, 814 (1-2) :179-185

[7] MODIFICATION OF SEIZURE ACTIVITY BY ELECTRICAL STIMULATION .2. MOTOR SEIZURE [J].

RACINE, RJ .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1972, 32 (03) :281-&

[8] KAINATE RECEPTORS IN EPILEPSY AND EXCITOTOXICITY [J].

Vincent, P. ;

Mulle, C. .

NEUROSCIENCE, 2009, 158 (01) :309-323

← 1 →