Nanoceria exhibit redox state-dependent catalase mimetic activity

被引：953

作者：

Pirmohamed, Talib ^{[1
]}

Dowding, Janet M. ^{[1
]}

Singh, Sanjay ^{[1
]}

Wasserman, Brian ^{[1
]}

Heckert, Eric ^{[1
]}

Karakoti, Ajay S. ^{[2
,3
]}

King, Jessica E. S. ^{[2
,3
]}

Seal, Sudipta ^{[2
,3
]}

Self, William T. ^{[1
]}

机构：

[1] Burnett Sch Biomed Sci, Orlando, FL USA

[2] Univ Cent Florida, Mech Mat & Aerosp Engn Nanosci & Technol Ctr, Orlando, FL 32816 USA

[3] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 16期

关键词：

SUPEROXIDE-DISMUTASE; OXIDE NANOPARTICLES; OXIDATIVE STRESS; CERIUM; NANOSTRUCTURES;

D O I：

10.1039/b922024k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study we have found that cerium oxide nanoparticles exhibit catalase mimetic activity. Surprisingly, the catalase mimetic activity correlates with a reduced level of cerium in the +3 state, in contrast to the relationship between surface charge and superoxide scavenging properties.

引用

页码：2736 / 2738

页数：3

共 17 条

[1] Mitochondrial free radical generation, oxidative stress, and aging [J].

Cadenas, E ;

Davies, KJA .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (3-4) :222-230

[2] Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides [J].

Chen, Junping ;

Patil, Swanand ;

Seal, Sudipta ;

McGinnis, James F. .

NATURE NANOTECHNOLOGY, 2006, 1 (02) :142-150

[3] Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function [J].

Csiszar, A ;

Ungvari, Z ;

Edwards, JG ;

Kaminski, P ;

Wolin, MS ;

Koller, A ;

Kaley, G .

CIRCULATION RESEARCH, 2002, 90 (11) :1159-1166

[4] Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons [J].

Das, Mainak ;

Patil, Swanand ;

Bhargava, Neelima ;

Kang, Jung-Fong ;

Riedel, Lisa M. ;

Seal, Sudipta ;

Hickman, James J. .

BIOMATERIALS, 2007, 28 (10) :1918-1925

[5] Neurodegenerative diseases and oxidative stress [J].

Emerit, J ;

Edeas, A ;

Bricaire, F .

BIOMEDICINE & PHARMACOTHERAPY, 2004, 58 (01) :39-46

[6] Low-frequency 1/f-noise in (La0.7Sr0.3MnO3)0.95:(MgO)0.05 nanocomposite films -: art. no. 082509 [J].

Esseling, M ;

Moshnyaga, V ;

Samwer, K ;

Marx, A ;

Gross, R .

APPLIED PHYSICS LETTERS, 2005, 87 (08)

[7]

GONZALEZ PK, 1995, J PHARMACOL EXP THER, V275, P798

[8] Aging and disease: Extending functional life span [J].

Harman, D .

PHARMACOLOGICAL INTERVENTION IN AGING AND AGE-ASSOCIATED DISORDERS: PROCEEDINGS OF THE SIXTH CONGRESS OF THE INTERNATIONAL ASSOCIATION OF BIOMEDICAL GERONTOLOGY, 1996, 786 :321-336

[9] The role of cerium redox state in the SOD mimetic activity of nanoceria [J].

Heckert, Eric G. ;

Karakoti, Ajay S. ;

Seal, Sudipta ;

Self, William T. .

BIOMATERIALS, 2008, 29 (18) :2705-2709

[10] Self-assembly of cerium oxide nanostructures in ice molds [J].

Karakoti, Ajay S. ;

Kuchibhatla, Satyanarayana V. N. T. ;

Baer, Donald R. ;

Thevuthasan, Suntharampillai ;

Sayle, Dean C. ;

Seal, Sudipta .

SMALL, 2008, 4 (08) :1210-1216

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