Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule

被引：42

作者：

Cai, Ming ^{[1
,2
]}

Wang, Hongbiao ^{[3
]}

Song, Haihan ^{[4
]}

Yang, Ruoyu ^{[5
]}

Wang, Liyan ^{[5
]}

Xue, Xiangli ^{[6
]}

Sun, Wanju ^{[4
]}

Hu, Jingyun ^{[4
]}

机构：

[1] Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Rehabil Med, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Biox Inst, Shanghai, Peoples R China

[3] Shanghai Univ Med & Hlth Sci, Dept Phys Educ, Shanghai, Peoples R China

[4] Shanghai Pudong New Area Peoples Hosp, Cent Lab, Shanghai, Peoples R China

[5] Shanghai Univ Med & Hlth Sci, Coll Rehabil Sci, Shanghai, Peoples R China

[6] Shanghai Univ Sport, Key Lab Exercise & Hlth Sci Minist Educ, Shanghai, Peoples R China

来源：

FRONTIERS IN NUTRITION | 2022年 / 9卷

基金：

中国博士后科学基金;

关键词：

lactate; brain function; brain diseases; energy substrates; signal molecule; CONTROLLED CORTICAL IMPACT; MONOCARBOXYLATE TRANSPORTERS; EXTRACELLULAR LACTATE; END-PRODUCT; RAT-LIVER; SYNAPTIC PLASTICITY; CEREBRAL METABOLISM; IMPAIRED AWARENESS; GLUCOSE-METABOLISM; GLYCOGEN DECREASES;

D O I：

10.3389/fnut.2022.800901

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanisms of brain lactate have now been described. A theoretical framework on the relevance between lactate and brain function and brain diseases is presented. This review begins with the source and route of lactate formation in the brain and food; goes on to uncover the regulatory effect of lactate on brain function; and progresses to gathering the application and concentration variation of lactate in several brain diseases (diabetic encephalopathy, Alzheimer's disease, stroke, traumatic brain injury, and epilepsy) treatment. Finally, the dual role of lactate in the brain is discussed. This review highlights the biological effect of lactate, especially L-lactate, in brain function and disease studies and amplifies our understanding of past research.

引用

页数：17

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