Clinical characteristics of dilated cardiomyopathy with pulmonary hypertension

Objective: The goal of this study was to evaluate the clinical characteristics of patients with dilated cardiomyopathy (DCM) with pulmonary hypertension (PH), to explore risk factors of patients with PH secondary to DCM. Methods: Two hundred and fifty DCM patients were retrospectively analyzed. The characteristics of basic clinical data, ultrasound index, biochemical index, RDW, and PDW were analyzed. Correlation between the above indexes and PASP or LVEF was investigated. Risk factors of PH secondary to DCM were analyzed by logistic regression analysis. Results: Length of medical history of the DCM-PH group (DCM with PH) was higher than that of the DCM group (DCM without PH), the percentage of patients with symptoms and signs of right heart failure of the DCM-PH group was higher than that of the DCM group (p<0.01). PASP was positively correlated with LAD, LVDd, RVDd, NT-proBNP, UA, Cr, and CYC, length of medical history, RAD, TBIL, RDW-SD, RDW-CV, PDW, P-LCR, MPV, were negatively correlated with LVEF and PA. LVEF was positively correlated with PA, negatively correlated with PASP, NT-proBNP, lengths of medical history, LAD, LVDd, RAD, RVDd, TBIL, UA, Cr, CYC, RDW-CV, and P-LCR. Conclusion: With increased PASP and decreased LVEF, the abnormality of ultrasound indexes, biochemical indexes, and RDW and PDW were more significant. Therefore, this study provides the basis of prevention, clinical diagnosis, and treatment for the occurrence of PH in patients with DCM.