High-contrast grating resonators for label-free detection of disease biomarkers

被引：53
作者：
Sun, Tianbo [1 ]
Kan, Shu [2 ]
Marriott, Gerard [2 ]
Chang-Hasnain, Connie [1 ]
机构：
[1] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词：
MYOCARDIAL-INFARCTION; DIAGNOSIS; SENSOR; ELISA;
D O I：
10.1038/srep27482
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of similar to 500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached antibodies with their respective antigens. The device can detect serum cardiac troponin I, a biomarker of cardiac disease to 100 pg/ml within 4 mins, which is faster, and as sensitive as current enzyme-linked immuno-assays for cTnI.
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页数：7
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