High-contrast grating resonators for label-free detection of disease biomarkers

被引：53
作者：
Sun, Tianbo [1 ]
Kan, Shu [2 ]
Marriott, Gerard [2 ]
Chang-Hasnain, Connie [1 ]
机构：
[1] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词：
MYOCARDIAL-INFARCTION; DIAGNOSIS; SENSOR; ELISA;
D O I：
10.1038/srep27482
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of similar to 500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached antibodies with their respective antigens. The device can detect serum cardiac troponin I, a biomarker of cardiac disease to 100 pg/ml within 4 mins, which is faster, and as sensitive as current enzyme-linked immuno-assays for cTnI.
引用
收藏
页数：7
相关论文
共 25 条
  • [1] [Anonymous], OPT EXP
  • [2] Large-scale plasmonic microarrays for label-free high-throughput screening
    Chang, Tsung-Yao
    Huang, Min
    Yanik, Ahmet Ali
    Tsai, Hsin-Yu
    Shi, Peng
    Aksu, Serap
    Yanik, Mehmet Fatih
    Altug, Hatice
    [J]. LAB ON A CHIP, 2011, 11 (21) : 3596 - 3602
  • [3] High-contrast gratings for integrated optoelectronics
    Chang-Hasnain, Connie J.
    Yang, Weijian
    [J]. ADVANCES IN OPTICS AND PHOTONICS, 2012, 4 (03): : 379 - 440
  • [4] Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view
    Coskun, Ahmet F.
    Cetin, Arif E.
    Galarreta, Betty C.
    Alvarez, Daniel Adrianzen
    Altug, Hatice
    Ozcan, Aydogan
    [J]. SCIENTIFIC REPORTS, 2014, 4
  • [5] A plastic colorimetric resonant optical biosensor for multiparallel detection of label-free biochemical interactions
    Cunningham, B
    Lin, B
    Qiu, J
    Li, P
    Pepper, J
    Hugh, B
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2002, 85 (03) : 219 - 226
  • [6] Plasmonic ELISA for the detection of analytes at ultralow concentrations with the naked eye
    de la Rica, Roberto
    Stevens, Molly M.
    [J]. NATURE PROTOCOLS, 2013, 8 (09) : 1759 - 1764
  • [7] Silicon-on-Insulator microring resonator for sensitive and label-free biosensing
    De Vos, Katrien
    Bartolozzi, Irene
    Schacht, Etienne
    Bienstman, Peter
    Baets, Roel
    [J]. OPTICS EXPRESS, 2007, 15 (12): : 7610 - 7615
  • [8] Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
  • [9] Femtomolar detection of prostate-specific antigen: An immunoassay based on surface-enhanced Raman scattering and immunogold labels
    Grubisha, DS
    Lipert, RJ
    Park, HY
    Driskell, J
    Porter, MD
    [J]. ANALYTICAL CHEMISTRY, 2003, 75 (21) : 5936 - 5943
  • [10] Ultrasensitive carbon nanotube-based biosensors using antibody-binding fragments
    Kim, Jun Pyo
    Lee, Byung Yang
    Hong, Seunghun
    Sim, Sang Jun
    [J]. ANALYTICAL BIOCHEMISTRY, 2008, 381 (02) : 193 - 198
123