Metal complexes of cyclen and cyclam derivatives useful for medical applications:: a discussion based on thermodynamic stability constants and structural data

被引：150
作者：
Delgado, Rita
Felix, Vitor
Lima, Luis M. P.
Price, David W.
机构：
[1] Univ Nebraska, Inst Tecnol Quim & Biol, P-2781901 Oeiras, Portugal
[2] Inst Super Tecn, P-1049001 Lisbon, Portugal
[3] Univ Aveiro, Dept Quim, CICECO, P-3810193 Aveiro, Portugal
[4] AWE Aldermaston, Reading RG7 4PR, Berks, England
[5] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England
来源：
DALTON TRANSACTIONS | 2007年 / 26期
关键词：
D O I：
10.1039/b704360k
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of the most common chelators used in magnetic resonance imaging ( MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X- ray structures and theoretical studies.
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收藏
页码：2734 / 2745
页数：12
相关论文
共 86 条
[71]   METAL-COMPLEXES OF MACROCYCLIC LIGANDS .24. BINUCLEAR COMPLEXES WITH TETRAAZAMACROCYCLE-N,N',N'',N'''-TETRAACETIC ACIDS [J].
RIESEN, A ;
ZEHNDER, M ;
KADEN, TA .
HELVETICA CHIMICA ACTA, 1986, 69 (08) :2074-2080
[72]   CRYSTAL-STRUCTURES OF 2 BINUCLEAR CU-2+ COMPLEXES WITH 1,4,7,10-TETRA-AZACYCLODODECANE-N,N',N'',N'''-TETRA-ACETIC ACID AND 1,4,8,11-TETRA-AZACYCLOTETRADECANE-N,N',N'',N'''-TETRA-ACETIC ACID [J].
RIESEN, A ;
ZEHNDER, M ;
KADEN, TA .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, (19) :1336-1338
[73]   Comparison of four bifunctional chelates for radiolabeling monoclonal antibodies with copper radioisotopes: Biodistribution and metabolism [J].
Rogers, BE ;
Anderson, CJ ;
Connett, JM ;
Guo, LW ;
Edwards, WB ;
Sherman, ELC ;
Zinn, KR ;
Welch, MJ .
BIOCONJUGATE CHEMISTRY, 1996, 7 (04) :511-522
[74]  
Rohovec J, 2000, EUR J INORG CHEM, P195
[75]   Synthesis, crystal structures and NMR and luminescence spectra of lanthanide complexes of 1,4,7,10-tetraazacyclododecane with N-methylene(phenyl)phosphinic acid pendant arms [J].
Rohovec, J ;
Vojtísek, P ;
Hermann, P ;
Mosinger, J ;
Zák, Z ;
Lukes, I .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1999, (20) :3585-3592
[76]   Lanthanide(III) complexes of a mono (methylphosphonate) analogue of H4dota:: The influence of protonation of the phosphonate moiety on the TSAP/SAP isomer ratio and the water exchange rate [J].
Rudovsky, J ;
Cígler, P ;
Kotek, J ;
Hermann, P ;
Vojtísek, P ;
Lukes, I ;
Peters, JA ;
Vander Elst, L ;
Muller, RN .
CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (08) :2373-2384
[77]   Characterization of lanthanide(III) DOTP complexes: Thermodynamics, protonation, and coordination to alkali metal ions [J].
Sherry, AD ;
Ren, J ;
Huskens, J ;
Brucher, E ;
Toth, E ;
Geraldes, CFCG ;
Castro, MMCA ;
Cacheris, WP .
INORGANIC CHEMISTRY, 1996, 35 (16) :4604-4612
[78]   CRYSTAL AND MOLECULAR-STRUCTURE OF SODIUM AQUO(1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETATO)EUROPATE(III) TETRAHYDRATE, NA+(EUDOTA.H2O)-.4H2O, AND ITS RELEVANCE TO NMR-STUDIES OF THE CONFORMATIONAL BEHAVIOR OF THE LANTHANIDE COMPLEXES FORMED BY THE MACROCYCLIC LIGAND DOTA [J].
SPIRLET, MR ;
REBIZANT, J ;
DESREUX, JF ;
LONCIN, MF .
INORGANIC CHEMISTRY, 1984, 23 (03) :359-363
[79]   STRUCTURAL CHARACTERIZATION OF A TERBIUM(III) COMPLEX WITH 1,4,8,11-TETRAAZACYCLOTETRADECANE-1,4,8,11-TETRAACETIC ACID - LANTHANIDE IONS AND THE CONFORMATION OF THE 14-MEMBERED MACROCYCLES [J].
SPIRLET, MR ;
REBIZANT, J ;
LONCIN, MF ;
DESREUX, JF .
INORGANIC CHEMISTRY, 1984, 23 (25) :4278-4283
[80]   THE X-RAY STRUCTURE OF 1,4,8,11-TETRAAZACYCLOTETRADECANE-1,4,8,11-TETRAACETIC ACID AND ITS RELEVANCE TO THE PROTONATION OF POLYAZA POLYCARBOXYLIC MACROCYCLES [J].
SPIRLET, MR ;
REBIZANT, J ;
BARTHELEMY, PP ;
DESREUX, JF .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1991, (09) :2477-2481
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