Metal complexes of cyclen and cyclam derivatives useful for medical applications:: a discussion based on thermodynamic stability constants and structural data

被引：150
作者：
Delgado, Rita
Felix, Vitor
Lima, Luis M. P.
Price, David W.
机构：
[1] Univ Nebraska, Inst Tecnol Quim & Biol, P-2781901 Oeiras, Portugal
[2] Inst Super Tecn, P-1049001 Lisbon, Portugal
[3] Univ Aveiro, Dept Quim, CICECO, P-3810193 Aveiro, Portugal
[4] AWE Aldermaston, Reading RG7 4PR, Berks, England
[5] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England
来源：
DALTON TRANSACTIONS | 2007年 / 26期
关键词：
D O I：
10.1039/b704360k
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of the most common chelators used in magnetic resonance imaging ( MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X- ray structures and theoretical studies.
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页码：2734 / 2745
页数：12
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