Glutathione and the response of malignant cells to chemotherapy

被引：28
作者：
Kearns, PR [1 ]
Hall, AG [1 ]
机构：
[1] Newcastle Univ, Sch Med, Dept Paediat Oncol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
DRUG DISCOVERY TODAY | 1998年 / 3卷 / 03期
关键词：
D O I：
10.1016/S1359-6446(97)01156-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the past, the role of glutathione (GSH) in the production of drug resistance was assumed to be limited to electrophilic agents such as the bifunctional alkylating agents and cisplatin. Recently, however, evidence has emerged that links GSH homeostasis with regulation of the multidrug-resistance-related protein and the control of apoptotic cell death. These findings open up new avenues for the discovery of drugs that augment anticancer agents already in use or that have cytotoxic potential in their own right.
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页码：113 / 121
页数：9
相关论文
共 85 条
[1]   REDOX REGULATION OF FOS AND JUN DNA-BINDING ACTIVITY INVITRO [J].
ABATE, C ;
PATEL, L ;
RAUSCHER, FJ ;
CURRAN, T .
SCIENCE, 1990, 249 (4973) :1157-1161
[2]   PHASE-I CLINICAL-TRIAL OF INTRAVENOUS L-BUTHIONINE SULFOXIMINE AND MELPHALAN - AN ATTEMPT AT MODULATION OF GLUTATHIONE [J].
BAILEY, HH ;
MULCAHY, RT ;
TUTSCH, KD ;
ARZOOMANIAN, RZ ;
ALBERTI, D ;
TOMBES, MB ;
WILDING, G ;
POMPLUN, M ;
SPRIGGS, DR .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (01) :194-205
[3]  
BATIST G, 1986, J BIOL CHEM, V261, P5544
[4]  
BEAVER JP, 1995, EUR J CELL BIOL, V68, P47
[5]   Hydrogen peroxide in relation to proliferation and apoptosis in BHK-21 hamster fibroblasts [J].
Burdon, RH ;
Gill, V ;
Alliangana, D .
FREE RADICAL RESEARCH, 1996, 24 (02) :81-93
[6]  
CAMPBELL JAH, 1991, CANCER, V67, P1608, DOI 10.1002/1097-0142(19910315)67:6<1608::AID-CNCR2820670623>3.0.CO
[7]  
2-S
[8]   ROLE OF CELLULAR GLUTATHIONE AND GLUTATHIONE-S-TRANSFERASE IN THE EXPRESSION OF ALKYLATING AGENT CYTOTOXICITY IN HUMAN BREAST-CANCER CELLS [J].
CHEN, G ;
WAXMAN, DJ .
BIOCHEMICAL PHARMACOLOGY, 1994, 47 (06) :1079-1087
[9]   IDENTIFICATION OF GLUTATHIONE-S-TRANSFERASE AS A DETERMINANT OF 4-HYDROPEROXYCYCLOPHOSPHAMIDE RESISTANCE IN HUMAN BREAST-CANCER CELLS [J].
CHEN, GA ;
WAXMAN, DJ .
BIOCHEMICAL PHARMACOLOGY, 1995, 49 (11) :1691-1701
[10]   ENZYMATIC CONJUGATION OF CHLORAMBUCIL WITH GLUTATHIONE BY HUMAN GLUTATHIONE S-TRANSFERASES AND INHIBITION BY ETHACRYNIC-ACID [J].
CIACCIO, PJ ;
TEW, KD ;
LACRETA, FP .
BIOCHEMICAL PHARMACOLOGY, 1991, 42 (07) :1504-1507
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