ER stress response: Getting the UPR hand on misfolded proteins

被引：171

作者：

Hampton, RY ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol 0347, La Jolla, CA 92093 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 14期

关键词：

D O I：

10.1016/S0960-9822(00)00583-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unfolded proteins are constantly delivered to the ER lumen, where they must be removed by folding or degradation. Recent studies show that the 'unfolded protein response' controls essentially all aspects of ER function, coordinating these two fates for misfolded proteins in a process necessary for normal cell life.

引用

页码：R518 / R521

页数：4

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