Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway

被引：19

作者：

Lee, Seul Gi ^{[1
]}

Kim, Jin Soo ^{[1
]}

Min, Kyoungjin ^{[2
]}

Kwon, Taeg Kyu ^{[2
]}

Nam, Ju-Ock ^{[1
,3
]}

机构：

[1] Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 41566, South Korea

[2] Keimyung Univ, Sch Med, Dept Immunol, 2800 Dalgubeoldaero, Daegu 704701, South Korea

[3] Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2018年 / 293卷

基金：

新加坡国家研究基金会;

关键词：

3T3-L1; adipocytes; Anti-adipogenic; Hispidulin; PPAR gamma; Sage; ANTIOBESITY; DIFFERENTIATION; METABOLISM; CANCER;

D O I：

10.1016/j.cbi.2018.07.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hispidulin, a natural flavone, has been reported to have diverse pharmacological effects, including antifungal, antioxidant, and antithrombotic properties. However, an anti-adipogenic effect has not yet been reported, which is the focus of the current study. Hispidulin suppressed the differentiation of adipocytes and cellular lipid accumulation without cytotoxicity. Treatment with hispidulin at concentrations of 10, 20, and 40 mu M reduced intracellular lipids by 88.1%, 81.9%, and 75.8%, respectively. In addition, hispidulin reduced mRNA and protein expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) and adiponectin. To our knowledge, these results are the first evidence of the anti-adipogenic effects of hispidulin in 3T3-L1 adipocytes, indicating that hispidulin has potential as a novel anti-obesity therapeutic.

引用

页码：89 / 93

页数：5

共 27 条

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