Fibroblasts and macrophages: Collaborators in tissue homeostasis

被引：31

作者：

Franklin, Ruth A. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[2] Harvard Med Sch, Dept Immunol, 77 Ave Louis Pasteur,4BC 820, Boston, MA 02115 USA

来源：

IMMUNOLOGICAL REVIEWS | 2021年 / 302卷 / 01期

关键词：

cell circuits; cell-cell communication; fibroblasts; homeostasis; inflammation; macrophages; ARTHRITIS SYNOVIAL FIBROBLASTS; STEM-CELL NICHES; RETICULAR CELLS; STROMAL CELLS; ALVEOLAR MACROPHAGES; GROWTH-FACTOR; MESENCHYMAL TRANSITION; TUMOR PROGRESSION; GENE-EXPRESSION; GERMINAL CENTER;

D O I：

10.1111/imr.12989

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fibroblasts and macrophages are universal cell types across all mammalian tissues. These cells differ in many ways including their cellular origins; dynamics of renewal, recruitment, and motility within tissues; roles in tissue structure and secretion of signaling molecules; and contributions to the activation and progression of immune responses. However, many of the features that make these two cell types unique are not opposing, but instead complementary. This review will present cell-cell communication in this context and discuss how complementarity makes fibroblasts and macrophages highly compatible partners in the maintenance of tissue homeostasis.

引用

页码：86 / 103

页数：18

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