Optimized scintillator YAG:Pr nanoparticles for X-ray inducible photodynamic therapy

被引：11

作者：

Sapre, Ajay A. ^{[1
]}

Novitskaya, Ekaterina ^{[2
]}

Vakharia, Ved ^{[2
]}

Cota, Alejandro ^{[2
]}

Wrasidlo, Wolfgang ^{[3
]}

Hanrahan, Stephen M. ^{[4
]}

Derenzo, Stephen ^{[4
]}

Makale, Milan T. ^{[5
]}

Graeve, Olivia A. ^{[2
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, 9500 Gilman Dr MC 0412, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Mech & Aerosp Engn, 9500 Gilman Dr MC 0411, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Neurosci, 9500 Gilman Dr MC 0662, La Jolla, CA 92093 USA

[4] Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Cellular & Tissue Imaging Dept, 1 Cyclotron Rd,M-S 55-121, Berkeley, CA 94720 USA

[5] Univ Calif San Diego, Dept Radiat Med & Appl Sci, 3855 Hlth Sci Dr 0819, La Jolla, CA 92093 USA

来源：

MATERIALS LETTERS | 2018年 / 228卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

YAG; Praseodymium; X-ray inducible photodynamic therapy; Nanoparticles; Scintillator; PULSE-RADIOLYSIS; ALUMINUM; PHOSPHOR; CLEARANCE; POLYMER;

D O I：

10.1016/j.matlet.2018.05.090

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We describe a sol-gel synthetic method for the production of praseodymium-doped yttrium aluminum garnet (YAG) nanoparticles suitable for X-ray inducible photodynamic therapy (X-PDT). Our sol-gel based approach was optimized by varying temperature and time of calcination, resulting in nanoparticles that were smooth, spherical, and 50-200 nm in crystallite size. The powders were uniformly coated with a thin (10 nm) layer of silica to facilitate surface conjugation with functional moieties. Measurements of photon flux revealed that coated and uncoated powders emitted a similar photon emission spectrum in response to 50 keVp X-rays. We also determined that the presence of silica did not significantly reduce flux and the emission peak had a maximum at approximately 320 nm. Thus, these YAG:Pr powders are suitable candidates for future in vivo X-PDT studies. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：49 / 52

页数：4

共 29 条

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