Abnormal transitions of dynamic functional connectivity states in bipolar disorder: A whole-brain resting-state fMRI study

被引:19
作者
Du, Mengjiao [1 ,2 ,3 ]
Zhang, Li [1 ,2 ,3 ]
Li, Linling [1 ,2 ,3 ]
Ji, Erni [5 ]
Han, Xue [6 ]
Huang, Gan [1 ,2 ,3 ]
Liang, Zhen [1 ,2 ,3 ]
Shi, Li [1 ,2 ,3 ]
Yang, Haichen [5 ]
Zhang, Zhiguo [1 ,2 ,3 ,4 ]
机构
[1] Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Shenzhen 518060, Peoples R China
[2] Guangdong Prov Key Lab Biomed Measurements & Ultr, Shenzhen 518060, Peoples R China
[3] Marshall Lab Biomed Engn, Shenzhen 518060, Peoples R China
[4] Peng Cheng Lab, Shenzhen 518055, Peoples R China
[5] Shenzhen Mental Hlth Ctr, Dept Bipolar Disorders, Shenzhen Key Lab Psychol Healthcare, Shenzhen 518020, Peoples R China
[6] Shenzhen Nanshan Ctr Chron Dis Control, Dept Mental Hlth, Shenzhen 518060, Peoples R China
基金
中国国家自然科学基金;
关键词
Dynamic functional connectivity; bipolar disorder; functional magnetic resonance imaging; resting-state networks; zero-inflated Poisson regression; INFLATED POISSON REGRESSION; NETWORKS; SCALE; MRI; RELIABILITY; DEPRESSION; AMYGDALA; MODEL; TASK;
D O I
10.1016/j.jad.2021.04.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Dynamic functional connectivity (dFC) based on resting-state fMRI has attracted interest in the field of bipolar disorder (BD), because dFC can better capture the evolving processes of emotion and cognition, which are typically impaired in BD. However, previous dFC studies of BD have typically focused on specific seed brain regions or specific functional brain networks, and they have ignored global dynamic information interaction in the whole brain. This study is aimed to reveal aberrant and interpretable whole-brain dFC patterns of BD. Methods: The resting-state fMRI data collected from 35 euthymic BD patients and 30 healthy people. We developed a new dFC inference pipeline, including the sliding-window method, k-means clustering, a new permutation with zero-inflated Poisson regression method, and a similarity analysis for interpretable states, to examine the different patterns of dFC states between BD patients and healthy participants. Results: BD patients had significantly more frequent transitions between two specific dFC states, which were respectively close to high-level cognitive networks and low-level sensory networks, than healthy controls (p < 0.05, FDR). Limitations: The size of samples and other BD types need to be expanded to validate the results of this study. Possible confounding effect of medication. Conclusions: This study detected aberrant dFC pattern of BD, which indicated the increased lability of the processes of cognition and emotion in BD, and this finding could improve our understanding of the neuropathological mechanism of BD.
引用
收藏
页码:7 / 15
页数:9
相关论文
共 77 条
[1]  
Aggarwal CC, 2001, LECT NOTES COMPUT SC, V1973, P420
[2]   Emotion-regulation strategies across psychopathology: A meta-analytic review [J].
Aldao, Amelia ;
Nolen-Hoeksema, Susan ;
Schweizer, Susanne .
CLINICAL PSYCHOLOGY REVIEW, 2010, 30 (02) :217-237
[3]   Tracking Whole-Brain Connectivity Dynamics in the Resting State [J].
Allen, Elena A. ;
Damaraju, Eswar ;
Plis, Sergey M. ;
Erhardt, Erik B. ;
Eichele, Tom ;
Calhoun, Vince D. .
CEREBRAL CORTEX, 2014, 24 (03) :663-676
[4]   CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[5]   Associations between mood instability and emotional processing in a large cohort of bipolar patients [J].
Bilderbeck, A. C. ;
Reed, Z. E. ;
McMahon, H. C. ;
Atkinson, L. Z. ;
Price, J. ;
Geddes, J. R. ;
Goodwin, G. M. ;
Harmer, C. J. .
PSYCHOLOGICAL MEDICINE, 2016, 46 (15) :3151-3160
[6]   FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].
BISWAL, B ;
YETKIN, FZ ;
HAUGHTON, VM ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541
[7]   A functional magnetic resonance imaging study of bipolar disorder - State- and trait-related dysfunction in ventral prefrontal cortices [J].
Blumberg, HP ;
Leung, HC ;
Skudlarski, P ;
Lacadie, CM ;
Fredericks, CA ;
Harris, BC ;
Charney, DS ;
Gore, JC ;
Krystal, JH ;
Peterson, BS .
ARCHIVES OF GENERAL PSYCHIATRY, 2003, 60 (06) :601-609
[8]   Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise [J].
Bonsall, Michael B. ;
Geddes, John R. ;
Goodwin, Guy M. ;
Holmes, Emily A. .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2015, 12 (112)
[9]   Self-projection and the brain [J].
Buckner, Randy L. ;
Carroll, Daniel C. .
TRENDS IN COGNITIVE SCIENCES, 2007, 11 (02) :49-57
[10]   The Chronnectome: Time-Varying Connectivity Networks as the Next Frontier in fMRI Data Discovery [J].
Calhoun, Vince D. ;
Miller, Robyn ;
Pearlson, Godfrey ;
Adali, Tulay .
NEURON, 2014, 84 (02) :262-274