Age Differences in the Motor Control of Speech: An fMRI Study of Healthy Aging

被引:30
作者
Tremblay, Pascale [1 ,2 ]
Sato, Marc [3 ]
Deschamps, Isabelle [1 ,2 ]
机构
[1] Univ Laval, Dept Readaptat, Fac Med, Quebec City, PQ, Canada
[2] Inst Univ Sante Mentale Quebec, Ctr Res, Quebec City, PQ, Canada
[3] Univ Aix Marseille, CNRS, Lab Parole & Langage, Aix En Provence, France
基金
加拿大自然科学与工程研究理事会;
关键词
aging; speech production; movement time; primary motor cortex; premotor cortex; anterior insula; posterior cingulate gyrus; neural compensation; de-differentiation; POSTERIOR CINGULATE CORTEX; SURFACE-BASED ANALYSIS; BASAL GANGLIA; OLDER-ADULTS; FUNCTIONAL NEUROANATOMY; WORKING-MEMORY; CEREBELLAR CONTRIBUTIONS; COGNITIVE NEUROSCIENCE; SYLLABLE STRUCTURE; WORD RECOGNITION;
D O I
10.1002/hbm.23558
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Healthy aging is associated with a decline in cognitive, executive, and motor processes that are concomitant with changes in brain activation patterns, particularly at high complexity levels. While speech production relies on all these processes, and is known to decline with age, the mechanisms that underlie these changes remain poorly understood, despite the importance of communication on everyday life. In this cross-sectional group study, we investigated age differences in the neuromotor control of speech production by combining behavioral and functional magnetic resonance imaging (fMRI) data. Twenty-seven healthy adults underwent fMRI while performing a speech production task consisting in the articulation of nonwords of different sequential and motor complexity. Results demonstrate strong age differences in movement time (MT), with longer and more variable MT in older adults. The fMRI results revealed extensive age differences in the relationship between BOLD signal and MT, within and outside the sensorimotor system. Moreover, age differences were also found in relation to sequential complexity within the motor and attentional systems, reflecting both compensatory and de-differentiation mechanisms. At very high complexity level (high motor complexity and high sequence complexity), age differences were found in both MT data and BOLD response, which increased in several sensorimotor and executive control areas. Together, these results suggest that aging of motor and executive control mechanisms may contribute to age differences in speech production. These findings highlight the importance of studying functionally relevant behavior such as speech to understand the mechanisms of human brain aging. (C) 2017 Wiley Periodicals, Inc.
引用
收藏
页码:2751 / 2771
页数:21
相关论文
共 153 条
[1]   The contribution of the insula to motor aspects of speech production: A review and a hypothesis [J].
Ackermann, H ;
Riecker, A .
BRAIN AND LANGUAGE, 2004, 89 (02) :320-328
[2]   Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectives [J].
Ackermann, Hermann .
TRENDS IN NEUROSCIENCES, 2008, 31 (06) :265-272
[3]   The contribution of the cerebellum to speech production and speech perception: Clinical and functional imaging data [J].
Ackermann, Hermann ;
Mathiak, Klaus ;
Riecker, Axel .
CEREBELLUM, 2007, 6 (03) :202-213
[4]   Syllable frequency and syllable structure in apraxia of speech [J].
Aichert, I ;
Ziegler, W .
BRAIN AND LANGUAGE, 2004, 88 (01) :148-159
[5]   Finger Tapping Ability in Healthy Elderly and Young Adults [J].
Aoki, Tomoko ;
Fukuoka, Yoshiyuki .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2010, 42 (03) :449-455
[6]   Simplified intersubject averaging on the cortical surface using SUMA [J].
Argall, BD ;
Saad, ZS ;
Beauchamp, MS .
HUMAN BRAIN MAPPING, 2006, 27 (01) :14-27
[7]   Control of vocal loudness in young and old adults [J].
Baker, KK ;
Ramig, LO ;
Sapir, S ;
Luschei, ES ;
Smith, ME .
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 2001, 44 (02) :297-305
[8]   Role of the precentral gyrus of the insula in complex articulation [J].
Baldo, Juliana V. ;
Wilkins, David P. ;
Ogar, Jennifer ;
Willock, Sharon ;
Dronkers, Nina F. .
CORTEX, 2011, 47 (07) :800-807
[9]   Effector-independent voluntary timing:: behavioural and neuroimaging evidence [J].
Bengtsson, SL ;
Ehrsson, HH ;
Forssberg, H ;
Ullén, F .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (12) :3255-3265
[10]   Dissociating brain regions controlling the temporal and ordinal structure of learned movement sequences [J].
Bengtsson, SL ;
Ehrsson, HH ;
Forssberg, H ;
Ullén, F .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 19 (09) :2591-2602