A NOVEL METHOD FOR DETERMINING THE ARRIVAL TIME OF REFLECTED WAVE AT SINGLE SITE: VALIDATION USING PHASE CONTRAST MAGNETIC RESONANCE DATA

Characterization of the wave reflection and mainly its return time has significant clinical value in detecting cardiovascular and cerebrovascular diseases. Indeed, the return time is an indicator which is used to evaluate the performance of peripheral perfusion and the propagation speed for arterial stiffness measurement. The study is aimed at implementing a novel model based on cepstral analysis for estimation of the arrival time of reflected wave (t(0)). The proposed method is specially based on cepstral analysis of the simulated blood velocity wave by using the Matlab software. To achieve this aim, we used a theoretical bidimensional model to simulate blood flow velocity, and we combined this model with clinical data acquired in two healthy subjects using phase contrast magnetic resonance imaging (PCMRI). Values of the arrival time of reflected wave measured are similar to the theoretical values. The suggested model is validated in vivo. We can conclude that the novel approach described in this paper offers a promising efficient and convenient method to determinate noninvasively arrival time of reflected wave.