Salvianolic acid B induces browning in 3T3-L1 white adipocytes via activation of β3-AR and ERK signaling pathways

被引:6
作者
Pham, Huong Giang [1 ]
Dang, Trang Thi Huyen [1 ]
Yun, Jong Won [1 ]
机构
[1] Daegu Univ, Dept Biotechnol, Gyongsan 38453, Gyeongbuk, South Korea
基金
新加坡国家研究基金会;
关键词
Anti-obesity; Beige; Browning; Salvianolic acid B; Thermogenesis; HIGH-FAT DIET; ADIPOSE-TISSUE; BEIGE ADIPOCYTES; WEIGHT-GAIN; MAP KINASE; PROTECTS; MILTIORRHIZA; OBESITY; INJURY; CELL;
D O I
10.1016/j.jff.2021.104475
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Salvianolic acid B (Sal B), a natural compound extracted from Salvia miltiorrhiza (Danshen), is well known for its anti-oxidative activity and treatment of cardiovascular diseases. However, little is known about the functional roles of Sal B in white adipocytes. Therefore, this study aimed to investigate the functions of Sal B in 3T3-L1 white adipocytes, with a focus on white fat browning effect. Exposure to Sal B significantly increased the expressions of beige-specific genes and thermogenic marker proteins. Sal B also suppressed lipogenesis and enhanced lipolysis in white adipocytes. A mechanistic study revealed that Sal B stimulates white fat browning via beta 3-AR and ERK signaling pathways in an independent manner. In conclusion, our findings indicate that Sal B is beneficial in the prevention and treatment of obesity, at least in part by promoting thermogenesis.
引用
收藏
页数:9
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