RUNX transcription factors as key targets of TGF-β superfamily signaling

被引：314
作者：
Ito, Y
Miyazono, K
机构：
[1] Natl Univ Singapore, Inst Mol & Cell Biol, Singapore 117609, Singapore
[2] Natl Univ Singapore, Oncol Res Inst, Singapore 117609, Singapore
[3] Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Bunkyo Ku, Tokyo 1130033, Japan
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(03)00007-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.
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页码：43 / 47
页数：5
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