Tight junctions: is there a role in dermatology?

被引：33

作者：

Kirschner, Nina ^{[1
]}

Bohner, Claudia ^{[1
]}

Rachow, Susanne ^{[1
]}

Brandner, Johanna M. ^{[1
]}

机构：

[1] Univ Hosp Hamburg Eppendorf, Dept Dermatol & Venerol, D-20246 Hamburg, Germany

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2010年 / 302卷 / 07期

关键词：

Claudin; Occludin; ZO-1; JAM; Skin; Barrier; Proliferation; Differentiation; EPIDERMAL BARRIER FUNCTION; SQUAMOUS-CELL CARCINOMA; LANGERHANS CELLS; STRATIFIED EPITHELIA; ADHESION MOLECULES; PROTEINS OCCLUDIN; E-CADHERIN; EXPRESSION; CLAUDIN-1; SKIN;

D O I：

10.1007/s00403-010-1058-z

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A variety of tight junction (TJ) proteins including claudins, occludin, tricellulin, zonula occludens-proteins and junctional adhesion molecules have been identified in complex localization patterns in mammalian epidermis. Their expression and/or localization is frequently altered in skin diseases including skin tumors. However, our understanding of the function(s) of TJ and TJ proteins in the skin is, even though rapidly increasing, still limited. This review summarizes our current knowledge of the involvement of TJ and TJ proteins in mammalian skin in functions ascribed to TJ in simple epithelia, such as barrier function, polarity, gene expression, proliferation, differentiation, and vesicle transport.

引用

页码：483 / 493

页数：11

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