Cardiomyocyte Polyploidy and Implications for Heart Regeneration

被引：59

作者：

Gan, Peiheng ^{[1
,2
,3
]}

Patterson, Michaela ^{[4
,5
]}

Sucov, Henry M. ^{[1
,2
]}

机构：

[1] Med Univ S Carolina, Dept Regenerat Med & Cell Biol, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Med, Div Cardiol, Charleston, SC 29425 USA

[3] Univ Southern Calif, Keck Sch Med, Dept Stem Cell Biol & Regenerat Med, Los Angeles, CA 90033 USA

[4] Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI 53226 USA

[5] Med Coll Wisconsin, Cardiovasc Ctr, Milwaukee, WI 53226 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 82 | 2020年 / 82卷

基金：

美国国家卫生研究院;

关键词：

cardiomyocyte ploidy; binucleated; mononuclear diploid; heart regeneration; cardiomyocyte proliferation; CELL-CYCLE ARREST; MAMMALIAN HEART; CARDIAC MYOCYTES; DNA-SYNTHESIS; MOUSE HEART; PROLIFERATION; GROWTH; DEDIFFERENTIATION; DIFFERENTIATION; RECOVERY;

D O I：

10.1146/annurev-physiol-021119-034618

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In mammals, most cardiomyocytes (CMs) become polyploid (they have more than two complete sets of chromosomes). The purpose of this review is to evaluate assumptions about CM ploidy that are commonly discussed, even if not experimentally demonstrated, and to highlight key issues that are still to be resolved. Topics discussed here include (a) technical and conceptual difficulties in defining a polyploid CM, (b) the candidate role of reactive oxygen as a proximal trigger for the onset of polyploidy, (c) the relationship between polyploidization and other aspects of CM maturation, (d) recent insights related to the regenerative role of the subpopulation of CMs that are not polyploid, and (e) speculations as to why CMs become polyploid at all. New approaches to experimentally manipulate CM ploidy may resolve some of these long-standing and fundamental questions.

引用

页码：45 / 61

页数：17

共 84 条

[21] Dexamethasone Induces Cardiomyocyte Terminal Differentiation via Epigenetic Repression of Cyclin D2 Gene [J].