Synthesis of some new 3-[5-(2-oxo-2H-3-chromenyl)-1,3-oxazol-2-yl]-1,3-thiazolan-4-ones as antimicrobials

被引：5

作者：

Reddy, Cherkupally Sanjeeva ^{[1
]}

Rao, L. Sanjeeva ^{[1
]}

Devi, M. Vani ^{[1
]}

Kumar, G. Rajesh ^{[1
]}

Nagaraj, A. ^{[2
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India

[2] Telangana Univ, Dept Pharmaceut Chem, Nizamabad 503175, India

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 09期

关键词：

1,3-Thiazolan-4-ones; 2-Oxo-2H-chromenyl; 1,3-Oxazolyl; Antibacterial activity; THIAZOLIDIN-4-ONES; INHIBITION; COUMARIN; CP-060S; ACID;

D O I：

10.1016/j.cclet.2010.03.018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of some new 2-imino-5-[(Z)-1-(4-methylphenyl)methylidene]-3-[5-(2-oxo-2H-3-chromenyl)-1,3-oxazol-2-yl]-1,3-thiazolan-4-ones 5a-j has been synthesized and assayed for their antibacterial activity against Gram-positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p) and Micrococcus luteus (IFC 12708), and Gram-negative bacteria viz. Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028) and Escherichia coli (ATCC 25922). Among the screened compounds, 5d, 5e, 5f, 5g, and 5j exhibited potent inhibitory activity compared to standard drug, and emerged as potential molecules for further development. (C) 2010 Cherkupally Sanjeeva Reddy. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1045 / 1048

页数：4

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