Rapid Viral Rebound After 4 Years of Suppressive Therapy in a Seronegative HIV-1 Infected Infant Treated From Birth

被引：36

作者：

Butler, Karina M. ^{[1
,2
]}

Gavin, Patrick ^{[1
]}

Coughlan, Suzie ^{[3
]}

Rochford, Annette ^{[1
]}

Mc Donagh, Sinead ^{[1
]}

Cunningham, Orla ^{[4
]}

Poulsom, Hannah ^{[5
]}

Watters, Sarah A. ^{[6
]}

Klein, Nigel ^{[5
]}

机构：

[1] Our Ladys Childrens Hosp, Dept Infect Dis & Immunol, Crumlin, Ireland

[2] Univ Coll Dublin, Dept Paediat, UCD Sch Med & Med Sci, Dublin 2, Ireland

[3] Univ Coll Dublin, Natl Virus Reference Lab, Dublin 2, Ireland

[4] Coombe Womens Hosp, Dublin, Ireland

[5] UCL, Dept Infect Inflammat & Rheumatol, London WC1E 6BT, England

[6] UCL, Dept Infect & Immun, London WC1E 6BT, England

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2015年 / 34卷 / 03期

关键词：

HIV-1; seronegative infected infant; viral rebound; early ARV treatment; ANTIRETROVIRAL THERAPY; CHILDREN; RESERVOIRS; ABSENCE;

D O I：

10.1097/INF.0000000000000570

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Attention has focused on the possibility of cure for HIV infected infants if treated promptly after delivery. The "Mississippi baby," who had very prolonged remission after antiretroviral discontinuation, may represent a unique situation. We report an infant treated from birth, who seroreverted, remained virologically suppressed, and had undetectable HIV-1 RNA and DNA at 4 years of age, yet experienced virologic rebound within days of discontinuation of antiretroviral therapy.

引用

页码：E48 / E51

页数：4

共 13 条

[1] Evaluation of 4 Weeks' Neonatal Antiretroviral Prophylaxis as a Component of a Prevention of Mother-to-child Transmission Program in a Resource-rich Setting [J].

Ferguson, Wendy ;

Goode, Michele ;

Walsh, Amanda ;

Gavin, Patrick ;

Butler, Karina .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2011, 30 (05) :408-412

[2] Routine versus clinically driven laboratory monitoring and first-line antiretroviral therapy strategies in African children with HIV (ARROW): a 5-year open-label randomised factorial trial [J].

Gibb, Diana M. .

LANCET, 2013, 381 (9875) :1391-1403

[3] The Immunological and Virological Consequences of Planned Treatment Interruptions in Children with HIV Infection [J].

Klein, Nigel ;

Sefe, Delali ;

Mosconi, Ilaria ;

Zanchetta, Marisa ;

Castro, Hannah ;

Jacobsen, Marianne ;

Jones, Hannah ;

Bernardi, Stefania ;

Pillay, Deenan ;

Giaquinto, Carlo ;

Walker, A. Sarah ;

Gibb, Diana M. ;

De Rossi, Anita .

PLOS ONE, 2013, 8 (10)

[4] Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: Control of viral replication and absence of persistent HIV-1-specific immune responses [J].

Luzuriaga, K ;

McManus, M ;

Catalina, M ;

Mayack, S ;

Sharkey, M ;

Stevenson, M ;

Sullivan, JL .

JOURNAL OF VIROLOGY, 2000, 74 (15) :6984-6991

[5] HIV Type 1 (HIV-1) Proviral Reservoirs Decay Continuously Under Sustained Virologic Control in HIV-1-Infected Children Who Received Early Treatment [J].

Luzuriaga, Katherine ;

Tabak, Barbara ;

Garber, Manuel ;

Chen, Ya Hui ;

Ziemniak, Carrie ;

McManus, Margaret M. ;

Murray, Danielle ;

Strain, Matthew C. ;

Richman, Douglas D. ;

Chun, Tae-Wook ;

Cunningham, Coleen K. ;

Persaud, Deborah .

JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (10) :1529-1538

[6]

Payne H, 2014, TOP ANTIVIR MED, V22, P482

[7] Optimisation of antiretroviral therapy in HIV-infected children under 3 years of age [J].

Penazzato, Martina ;

Prendergast, Andrew J. ;

Muhe, Lulu M. ;

Tindyebwa, Denis ;

Abrams, Elaine .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2014, (05)

[8]

Persaud D, 2014, TOP ANTIVIR MED, V22, P126

[9]

Persaud D, 2014, TOP ANTIVIR MED, V22, P35

[10] Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy [J].

Persaud, Deborah ;

Ray, Stuart C. ;

Kajdas, Joleen ;

Ahonkhai, Aima ;

Siberry, George K. ;

Ferguson, Kimberly ;

Ziemniak, Carrie ;

Quinn, Thomas C. ;

Casazza, Joseph P. ;

Zeichner, Steven ;

Gange, Stephen J. ;

Watson, Douglas C. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (03) :381-390

← 1 2 →