Effect of coffee constituents, caffeine and caffeic acid on anxiety and lipopolysaccharide-induced sickness behavior in mice

被引：27
|
作者：
Mudgal, Jayesh [1 ]
Mallik, Sanchari Basu [1 ,2 ]
Nampoothiri, Madhavan [1 ]
Kinra, Manas [1 ]
Hall, Susan [2 ]
Grant, Gary D. [2 ]
Anoopkumar-Dukie, Shailendra [2 ]
Davey, Andrew K. [2 ]
Rao, C. Mallikarjuna [1 ]
Arora, Devinder [1 ,2 ]
机构：
[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmacol, Manipal 576104, India
[2] Griffith Univ, Sch Pharm & Pharmacol, MHIQ, QUM Network, Gold Coast, Australia
来源：
JOURNAL OF FUNCTIONAL FOODS | 2020年 / 64卷
关键词：
Caffeic acid; Caffeine; Sickness behavior; Neuroinflammation; Cytokines; Antioxidant; NF-KAPPA-B; ROSMARINIC ACID; NEUROINFLAMMATION; ACTIVATION; DEPRESSION; SYSTEM; IMPACT;
D O I：
10.1016/j.jff.2019.103638
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Caffeine (CAF) and polyphenolic compounds like caffeic acid (CA), chlorogenic acid and ferulic acid are commonly consumed through beverages and food. These constituents modulate immune system and impact the systemic inflammatory pathways. This study explored the modulatory effect of CA and CA + CAF on behavior and lipopolysaccharide (LPS) - induced neuroinflammation in mice. An array of behavioral tests suggest that CA (15 mg/kg) and CA + CAF (10 mg/kg + 5 mg/kg) express anxiolytic-like properties. Systemic administration of LPS (1.5 mg/kg) induced profound immobility, increased the systemic/brain cytokine (TNF-alpha and IL-6) levels and altered the host antioxidant defence in all the animals. Seven days pretreatment with CA alone and CA + CAF significantly reversed the LPS-induced behavioral changes and inflammatory markers. Our results suggest that the low doses of CA may offer a comparable anxiolytic and antidepressant effect when combined with CAF.
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页数：8
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