PET/CT in the Diagnosis and Workup of Sarcoidosis: Focus on Atypical Manifestations

被引:77
作者
Akaike, Gensuke [1 ]
Itani, Malak [1 ]
Shah, Hardik [1 ]
Ahuja, Jitesh [1 ]
Gunes, Burcak Yilmaz [2 ]
Assaker, Richard [3 ]
Behnia, Fatemeh [1 ]
机构
[1] Univ Washington, Dept Radiol, Div Nucl Med, 1959 NE Pacific St,Box 356113, Seattle, WA 98195 USA
[2] Istanbul Res & Training Hosp, Dept Nucl Med, Istanbul, Turkey
[3] Lebanese Amer Univ Med Ctr, Rizk Hosp, Beirut, Lebanon
关键词
F-18; FDG-PET/CT; POSITRON-EMISSION-TOMOGRAPHY; CLINICAL CHARACTERISTICS; CARDIAC SARCOIDOSIS; FOLLOW-UP; MANAGEMENT; THERAPY; NEUROSARCOIDOSIS; ENHANCEMENT; INVOLVEMENT;
D O I
10.1148/rg.2018180053
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Sarcoidosis is a multisystem disease characterized by the formation of noncaseating granulomas. Lung and intrathoracic lymph nodes are classic sites of involvement; however, sarcoidosis can affect any site in the body. The clinical course is extremely variable, and the imaging features are diverse and dependent on the affected site, degree of inflammation, and treatment the patient receives. Atypical manifestations and imaging findings can make diagnosis and/or management challenging. In addition, assessment of treatment response can be difficult in the setting of chronic disease. Fluorine 18 fluorodeoxyglucose (FDG) PET/CT is sensitive for assessment of the inflammatory activity of sarcoidosis in any organ. Although FDG PET/CT is not included in the standard workup for sarcoidosis, there has been growing evidence that supports the value of this examination in guiding diagnosis and management. FDG PET/CT may be especially useful for assessing reversible granuloma, treatment response, disease extent, occult disease, and cardiac or osseous sarcoidosis, and determining the most suitable biopsy site. Capability to image the entire body during a single examination is advantageous in cases of systemic disease such as sarcoidosis. The authors review the use of FDG PET/CT, providing up-to-date evidence and describing various cases of sarcoidosis in which FDG PET/CT has an important role in diagnosis and/or management. They also discuss the usefulness of FDG PET/CT in cases of selective manifestations of sarcoidosis.
引用
收藏
页码:1536 / 1549
页数:14
相关论文
共 51 条
[1]  
Aide N, 2007, Br J Radiol, V80, pe67, DOI 10.1259/bjr/33076108
[2]   Early 2'-Deoxy-2'-[18F]Fluoro-d-Glucose PET Metabolic Response after Corticosteroid Therapy to Differentiate Cancer from Sarcoidosis and Sarcoid-like Lesions [J].
Aide, Nicolas ;
Allouache, Djelila ;
Ollivier, Yann ;
de Raucourt, Sixtine ;
Switsers, Odile ;
Bardet, Stephane .
MOLECULAR IMAGING AND BIOLOGY, 2009, 11 (04) :224-228
[3]   Management of extrapulmonary sarcoidosis: challenges and solutions [J].
Al-Kofahi, Khalid ;
Korsten, Peter ;
Ascoli, Christian ;
Virupannavar, Shanti ;
Mirsaeidi, Mehdi ;
Chang, Ian ;
Qaqish, Naim ;
Saketkoo, Lesley A. ;
Baughman, Robert P. ;
Sweiss, Nadera J. .
THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2016, 12 :1623-1634
[4]   T2-Weighted Cardiac Magnetic Resonance Imaging of Edema in Myocardial Diseases [J].
Amano, Yasuo ;
Tachi, Masaki ;
Tani, Hitomi ;
Mizuno, Kyoichi ;
Kobayashi, Yasuhiro ;
Kumita, Shinichiro .
SCIENTIFIC WORLD JOURNAL, 2012,
[5]   Clinical characteristics of patients in a case control study of sarcoidosis [J].
Baughman, RP ;
Teirstein, AS ;
Judson, MA ;
Rossman, MD ;
Yeager, H ;
Bresnitz, EA ;
DePalo, L ;
Hunninghake, G ;
Iannuzzi, MC ;
Johns, CJ ;
McLennan, G ;
Moller, DR ;
Newman, LS ;
Rabin, DL ;
Rose, C ;
Rybicki, B ;
Weinberger, SE ;
Terrin, ML ;
Knatterud, GL ;
Cherniak, R .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (10) :1885-1889
[6]   Current and emerging pharmacological treatments for sarcoidosis: a review [J].
Beegle, Scott H. ;
Barba, Kerry ;
Gobunsuy, Romel ;
Judson, Marc A. .
DRUG DESIGN DEVELOPMENT AND THERAPY, 2013, 7 :325-338
[7]  
Bokhari S., FDG PET IS SUPERIOR
[8]  
Coker Robina Kate, 2009, Ther Clin Risk Manag, V5, P575
[9]   Orthopaedic Considerations in the Management of Skeletal Sarcoidosis [J].
Crawford, Brooke ;
Badlissi, Fadi ;
Lozano Calderon, Santiago A. .
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2018, 26 (06) :197-203
[10]   ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures [J].
Dilsizian, Vasken ;
Bacharach, Stephen L. ;
Beanlands, Rob S. ;
Bergmann, Steven R. ;
Delbeke, Dominique ;
Dorbala, Sharmila ;
Gropler, Robert J. ;
Knuuti, Juhani ;
Schelbert, Heinrich R. ;
Travin, Mark I. .
JOURNAL OF NUCLEAR CARDIOLOGY, 2016, 23 (05) :1187-1226