The Transformative Power of Biocatalysis in Convergent Synthesis
被引:27
作者:
Zetzsche, Lara E.
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机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Program Chem Biol, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Zetzsche, Lara E.
[1
,2
]
Chakrabarty, Suman
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机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Chakrabarty, Suman
[1
]
Narayan, Alison R. H.
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机构:
Univ Michigan, Life Sci Inst, Program Chem Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Narayan, Alison R. H.
[3
,4
]
机构:
[1] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Program Chem Biol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Life Sci Inst, Program Chem Biol, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Achieving convergent synthetic strategies has long been a gold standard in constructing complex molecular skeletons, allowing for the rapid generation of complexity in comparatively streamlined synthetic routes. Traditionally, biocatalysis has not played a prominent role in convergent laboratory synthesis, with the application of biocatalysts in convergent strategies primarily limited to the synthesis of chiral fragments. Although the use of enzymes to enable convergent synthetic approaches is relatively new and emerging, combining the efficiency of convergent transformations with the selectivity achievable through biocatalysis creates new opportunities for efficient synthetic strategies. This Perspective provides an overview of recent developments in biocatalytic strategies for convergent transformations and offers insights into the advantages of these methods compared to their small molecule-based counterparts.
机构:
AstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, SwedenAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
Bostrom, Jonas
;
Brown, Dean G.
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机构:
AstraZeneca, IMED Biotech Unit, Discovery Sci, Hit Discovery, Waltham, MA USAAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
Brown, Dean G.
;
Young, Robert J.
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机构:
GlaxoSmithKline R&D, NCE Med Chem, Stevenage, Herts, EnglandAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
Young, Robert J.
;
Keseru, Gyorgy M.
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机构:
Hungarian Acad Sci, Res Ctr Nat Sci, Med Chem Res Grp, Budapest, HungaryAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Chakrabarty, Suman
;
Romero, Evan O.
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机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Romero, Evan O.
;
Pyser, Joshua B.
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机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Pyser, Joshua B.
;
Yazarians, Jessica A.
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机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Yazarians, Jessica A.
;
Narayan, Alison R. H.
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机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Chakrabarty, Suman
;
Wang, Ye
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Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Wang, Ye
;
Perkins, Jonathan C.
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机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Perkins, Jonathan C.
;
Narayan, Alison R. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
机构:
AstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, SwedenAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
Bostrom, Jonas
;
Brown, Dean G.
论文数: 0引用数: 0
h-index: 0
机构:
AstraZeneca, IMED Biotech Unit, Discovery Sci, Hit Discovery, Waltham, MA USAAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
Brown, Dean G.
;
Young, Robert J.
论文数: 0引用数: 0
h-index: 0
机构:
GlaxoSmithKline R&D, NCE Med Chem, Stevenage, Herts, EnglandAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
Young, Robert J.
;
Keseru, Gyorgy M.
论文数: 0引用数: 0
h-index: 0
机构:
Hungarian Acad Sci, Res Ctr Nat Sci, Med Chem Res Grp, Budapest, HungaryAstraZeneca, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Chakrabarty, Suman
;
Romero, Evan O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Romero, Evan O.
;
Pyser, Joshua B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Pyser, Joshua B.
;
Yazarians, Jessica A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Yazarians, Jessica A.
;
Narayan, Alison R. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Chakrabarty, Suman
;
Wang, Ye
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Wang, Ye
;
Perkins, Jonathan C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Perkins, Jonathan C.
;
Narayan, Alison R. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA