New ingenane diterpenoids from Euphorbia kansui reverse multi-drug resistance

被引：8

作者：

Chen, You ^{[1
]}

Luo, Di ^{[1
]}

Chen, Ning-Yu ^{[1
]}

Zhang, Yue ^{[1
]}

Liang, Dong-E ^{[1
]}

Zhan, Zha-Jun ^{[1
]}

Ma, Lie-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

[2] Zhejiang Xinguang Pharmaceut Ltd Liabil Co, Shaoxing 312400, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2021年 / 43卷

基金：

中国国家自然科学基金;

关键词：

Euphorbia kansui; Diterpenoid; Ingenane; Kansuininol; MDR reversal; IN-VITRO; BIOLOGICAL-ACTIVITY; CELL-DIVISION; CANCER-CELLS; JATROPHANE; ROOTS; AGENTS;

D O I：

10.1016/j.phytol.2021.03.023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten ingenane-type diterpenoids, including two undescribed compounds named as kansuininols A-B (1-2), were isolated from the roots of Euphorbia kansui. Their structures were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS. Chemoreversal assays of these isolates were carried on adriamycin resistant human breast adenocarcinoma cell line MCF-7/ADR, and compounds 1-2 were identified as potent low-cytotoxic MDR modulators with greater chemoreversal ability than the positive drug verapamilti.

引用

页码：169 / 172

页数：4

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