Host genetic factors in susceptibility to HIV-1 infection and progression to AIDS

被引：26
作者：
Chatterjee, Koushik [1 ]
机构：
[1] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa
来源：
JOURNAL OF GENETICS | 2010年 / 89卷 / 01期
关键词：
HIV; AIDS; progression; genetics; polymorphism; TUMOR-NECROSIS-FACTOR; IMMUNODEFICIENCY-VIRUS TYPE-1; ALPHA PROMOTER REGION; T-LYMPHOCYTE EPITOPES; SINGLE AMINO-ACID; DISEASE PROGRESSION; HLA-B; CHEMOKINE RECEPTORS; CCR5; POLYMORPHISM;
D O I：
10.1007/s12041-010-0003-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
HIV-1 infection has rapidly spread worldwide and has become the leading cause of mortality in infectious diseases. The duration for development of AIDS (AIDS progression) is highly variable among HIV-1 infected individuals, ranging from 2-3 years to no signs of AIDS development in the entire lifetime. Several factors regulate the rate at which HIV-1 infection progresses to AIDS. Host genetic factors play an important role in the outcome of such complex or multifactor diseases as AIDS and are also known to regulate the rate of disease progression. This review focuses on the major host genes reported to affect the progression to AIDS in HIV-1 infected individuals.
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页码：109 / 116
页数：8
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