Host genetic factors in susceptibility to HIV-1 infection and progression to AIDS

被引：26

作者：

Chatterjee, Koushik ^{[1
]}

机构：

[1] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

来源：

JOURNAL OF GENETICS | 2010年 / 89卷 / 01期

关键词：

HIV; AIDS; progression; genetics; polymorphism; TUMOR-NECROSIS-FACTOR; IMMUNODEFICIENCY-VIRUS TYPE-1; ALPHA PROMOTER REGION; T-LYMPHOCYTE EPITOPES; SINGLE AMINO-ACID; DISEASE PROGRESSION; HLA-B; CHEMOKINE RECEPTORS; CCR5; POLYMORPHISM;

D O I：

10.1007/s12041-010-0003-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

HIV-1 infection has rapidly spread worldwide and has become the leading cause of mortality in infectious diseases. The duration for development of AIDS (AIDS progression) is highly variable among HIV-1 infected individuals, ranging from 2-3 years to no signs of AIDS development in the entire lifetime. Several factors regulate the rate at which HIV-1 infection progresses to AIDS. Host genetic factors play an important role in the outcome of such complex or multifactor diseases as AIDS and are also known to regulate the rate of disease progression. This review focuses on the major host genes reported to affect the progression to AIDS in HIV-1 infected individuals.

引用

页码：109 / 116

页数：8

共 104 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[2] APOBEC3G genetic variants and their influence on the progression to AIDS [J].

An, P ;

Bleiber, G ;

Duggal, P ;

Nelson, G ;

May, M ;

Mangeat, B ;

Alobwede, I ;

Trono, D ;

Vlahov, D ;

Donfield, S ;

Goedert, JJ ;

Phair, J ;

Buchbinder, S ;

O'Brien, SJ ;

Telenti, A ;

Winkler, CA .

JOURNAL OF VIROLOGY, 2004, 78 (20) :11070-11076

[3] Modulating influence on HIV/AIDS by interacting RANTES gene variants [J].

An, P ;

Nelson, GW ;

Wang, LH ;

Donfield, S ;

Goedert, JJ ;

Phair, J ;

Vlahov, D ;

Buchbinder, S ;

Farrar, WL ;

Modi, W ;

O'Brien, SJ ;

Winkler, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10002-10007

[4] HIV blocked by chemokine antagonist [J].

ArenzanaSeisdedos, F ;

Virelizier, JL ;

Rousset, D ;

ClarkLewis, I ;

Loetscher, P ;

Moser, B ;

Baggiolini, M .

NATURE, 1996, 383 (6599) :400-400

[5] NK cells and NKT cells in innate defense against viral infections [J].

Biron, CA ;

Brossay, L .

CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (04) :458-464

[6] Use of a combined ex vivo/in vivo population approach for screening of human genes involved in the human immunodeficiency virus type 1 life cycle for variants influencing disease progression [J].

Bleiber, G ;

May, M ;

Martinez, R ;

Meylan, P ;

Ott, H ;

Beckmann, JS ;

Telenti, A .

JOURNAL OF VIROLOGY, 2005, 79 (20) :12674-12680

[7] The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry [J].

Bleul, CC ;

Farzan, M ;

Choe, H ;

Parolin, C ;

ClarkLewis, I ;

Sodroski, J ;

Springer, TA .

NATURE, 1996, 382 (6594) :829-833

[8] The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes [J].

Bleul, CC ;

Wu, LJ ;

Hoxie, JA ;

Springer, TA ;

Mackay, CR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1925-1930

[9] Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection [J].

Bochud, Pierre-Yves ;

Hersberger, Martin ;

Taffe, Patrick ;

Bochud, Murielle ;

Stein, Catherine M. ;

Rodrigues, Stephanie D. ;

Calandra, Thierry ;

Francioli, Patrick ;

Telenti, Amalio ;

Speck, Roberto F. ;

Aderem, Alan .

AIDS, 2007, 21 (04) :441-446

[10] Cytokines in autoimmunity [J].

Brennan, FM ;

Feldmann, M .

CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (06) :872-877

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