CD44 deficiency leads to decreased proinflammatory cytokine production in lung induced by PCV2 in mice

被引：14

作者：

Fu, Qiang ^{[1
]}

Hou, Linbing ^{[1
]}

Xiao, Pingping ^{[1
]}

Guo, Chunhe ^{[1
]}

Chen, Yaosheng ^{[1
]}

Liu, Xiaohong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510006, Guangdong, Peoples R China

来源：

RESEARCH IN VETERINARY SCIENCE | 2014年 / 97卷 / 03期

基金：

星火计划;

关键词：

Porcine circovirus type 2; CD44; Pneumonia; CIRCOVIRUS TYPE-2 PCV2; MULTISYSTEMIC WASTING SYNDROME; MACROPHAGE RECRUITMENT; INFLAMMATORY RESPONSE; ANTIBACTERIAL DEFENSE; PORCINE CIRCOVIRUS-2; IMMUNE-SYSTEM; PIGS; EXPRESSION; HYALURONAN;

D O I：

10.1016/j.rvsc.2014.09.012

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Porcine circovirus type 2 (PCV2) is the primary etiological agent of postweaning multisystemic wasting syndrome (PMWS). CD44 is a widely expressed class I transmembrane glycoprotein implicated in immunological and inflammatory responses. In previous studies, the role of CD44 in host defense against microorganism infection remains controversial. The role of CD44 in host defense against PCV2 infection has never been studied before. In this study, we investigated the role of CD44 in the development of pneumonia induced by PCV2 in mice model. Upon infection, CD44 mRNA level in lung tissue was upregulated, and we confirmed a detrimental role of CD44 in host defense against PCV2 infection. The results demonstrated that CD44 deficiency could result in decreased proinflammatory cytokine production in lung induced by PCV2 in mice, suggesting a previously unrecognized role for CD44 in the development of pneumonia response to PCV2 infection. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：498 / 504

页数：7

共 46 条

[21] Viral replication and lesions in BALB/c mice experimentally inoculated with porcine circovirus isolated from a pig with postweaning multisystemic wasting disease [J].