Catalytic Asymmetric Synthesis of Benzobicyclo[3.2.1]octanes

被引：12

作者：

Anif Pasha, Mohammed ^{[1
]}

Peraka, Swamy ^{[1
]}

Ramachary, Dhevalapally B. ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Catalysis Lab, Hyderabad 500046, India

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 41期

关键词：

asymmetric catalysis; 3+2] annulation; lawsone; methanobenzo[f]azulenes; organocatalysis; PHOTOCHEMICAL APPROACH; SKELETON;

D O I：

10.1002/chem.202100985

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lawsone aldehydes were directly transformed into the biologically important, unique carbon skeleton of chiral methanobenzo[f]azulenes/methanodibenzo[a,d][7]annulenes in high dr and ee and in very good yields by using quinine-thiourea-catalyzed tandem Wittig/intramolecular Michael/intramolecular aldol reactions. This asymmetric catalytic tandem protocol will be highly useful because these final molecules are basic skeletons of important antibiotics.

引用

页码：10563 / 10568

页数：6

共 48 条

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