Thermal Responsive Ion Selectivity of Uranyl Peroxide Nanocages: An Inorganic Mimic of K+ Ion Channels

被引：33

作者：

Gao, Yunyi ^{[1
]}

Szymanowski, Jennifer E. S. ^{[2
]}

Sun, Xinyu ^{[1
]}

Burns, Peter C. ^{[2
]}

Liu, Tianbo ^{[1
]}

机构：

[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA

[2] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 24期

关键词：

ion channels; ion selectivity; self-assembly; uranyl peroxide nanocages; POTASSIUM CHANNELS; HYDRATION; NANOCAPSULES; CONDUCTION; CHEMISTRY; GUESTS; PORES; SHELL;

D O I：

10.1002/anie.201601852

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An actinyl peroxide cage cluster, Li48+mK12(OH)(m)-[UO2(O-2)(OH)](60) (H2O)(n) (m approximate to 20 and n approximate to 310; U-60), discriminates precisely between Na+ and K+ ions when heated to certain temperatures, a most essential feature for K+ selective filters. The U-60 clusters demonstrate several other features in common with K+ ion channels, including passive transport of K+ ions, a high flux rate, and the dehydration of U-60 and K+ ions. These qualities make U-60 (a pure inorganic cluster) a promising ion channel mimic in an aqueous environment. Laser light scattering (LLS) and isothermal titration calorimetry (ITC) studies revealed that the tailorable ion selectivity of U-60 clusters is a result of the thermal responsiveness of the U-60 hydration shells.

引用

页码：6887 / 6891

页数：5

共 37 条

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