Chronic Inflammatory Demyelinating Polyradiculoneuropathy

被引：8

作者：

Hughes, Richard ^{[1
]}

机构：

[1] Natl Hosp Neurol & Neurosurg, MRC Ctr Neuromuscular Dis, London WC1N 3BG, England

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2010年 / 30卷

关键词：

Chronic inflammatory demyelinating polyradiculoneuropathy; CIDP; IVIG; corticosteroids; immunosuppressants; mechanisms; VASCULITIC NEUROPATHY; CONTROLLED-TRIAL; POLYNEUROPATHY; PROTEIN; METHOTREXATE; CELLS;

D O I：

10.1007/s10875-010-9399-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic inflammatory demyelinating polyradiculoneuropathy is a chronic progressive or relapsing and remitting disease with a prevalence of up to 8.9 per 100,000. This review discusses possible mechanisms, none of which are proven, and describes the evidence for its treatment. Cochrane Reviews provide evidence that corticosteroids, intravenous immunoglobulin, and plasma exchange are effective short-term treatments. Attempts to confirm the efficacy of other immunosuppressant agents have not been successful, although they are often used in people whose disease is resistant to the first-line treatments. More and better trials are needed.

引用

页码：S70 / S73

页数：4

共 23 条

[1] Sural nerve T-cell receptor Vβ gene utilization in chronic inflammatory demyelinating polyneuropathy and vasculitic neuropathy [J].

Bosboom, WMJ ;

van den Berg, LH ;

Mollee, I ;

Sasker, LD ;

Jansen, J ;

Wokke, JHJ ;

Logtenberg, T .

NEUROLOGY, 2001, 56 (01) :74-81

[2] Impairment of circulating CD4+CD25+ regulatory T cells in patients with chronic inflammatory demyelinating polyradiculoneuropathy [J].

Chi, Li-Jun ;

Wang, Hua-Bing ;

Wang, Wei-Zhi .

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2008, 13 (01) :54-63

[3]

EFTIMOV F, 2002, COCHRANE DATABASE SY

[4] Treatment of chronic inflammatory demyelinating polyradiculoneuropathy with methotrexate [J].

Fialho, D ;

Chan, YC ;

Allen, DC ;

Reilly, MM ;

Hughes, RAC .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2006, 77 (04) :544-547

[5] Intramuscular interferon beta-1a in chronic inflammatory demyelinating polyradiculoneuropathy [J].

Hughes, R. A. C. ;

Gorson, K. C. ;

Cros, D. ;

Griffin, J. ;

Pollard, J. ;

Vallat, J. -M. ;

Maurer, S. L. ;

Riester, K. ;

Davar, G. ;

Dawson, K. ;

Sandrock, A. .

NEUROLOGY, 2010, 74 (08) :651-657

[6]

HUGHES RA, 2004, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD003280.PUB2

[7] Pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy [J].

Hughes, RAC ;

Allen, D ;

Makowska, A ;

Gregson, NA .

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2006, 11 (01) :30-46

[8]

Hughes RAC, 2005, J PERIPHER NERV SYST, V10, P220

[9] Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial [J].

Hughes, Richard A. C. ;

Donofrio, Peter ;

Bril, Vera ;

Dolakas, Marinos C. ;

Deng, Chunqin ;

Hanna, Kim ;

Hartung, Hans-Peter ;

Latov, Norman ;

Merkies, Ingemar S. J. ;

van Doom, Pieter A. .

LANCET NEUROLOGY, 2008, 7 (02) :136-144

[10] Randomised controlled trial of methotrexate for chronic inflammatory demyelinating polyradiculoneuropathy (RMC trial): a pilot, multicentre study [J].

Hughes, Richard A. C. .

LANCET NEUROLOGY, 2009, 8 (02) :158-164

← 1 2 3 →