Improvement of Atopic Dermatitis and Alopecia Universalis with Dupilumab: a case report

被引：4

作者：

Alotaibi, Lama ^{[1
]}

Alfawzan, Abdulrahman ^{[2
]}

Alharthi, Raghad ^{[2
]}

Al Sheikh, Afaf ^{[3
]}

机构：

[1] Prince Sultan Mil Med City, Div Dermatol, Dept Med, Riyadh, Saudi Arabia

[2] King Saud Univ Hlth Sci, Coll Med, Riyadh, Saudi Arabia

[3] King Abdul Aziz Med City, Div Dermatol, Dept Med, Riyadh, Saudi Arabia

来源：

DERMATOLOGY REPORTS | 2022年 / 14卷 / 02期

关键词：

Alopecia Areata; Alopecia Universalis; Atopic Dermatitis; Dupilumab; EXPRESSION;

D O I：

10.4081/dr.2022.9359

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dupilumab is an interleukin (IL)-4 receptor alpha antagonist that showed significant improvement of atopic dermatitis (AD). Many reports have shown significant resolution of alopecia areata, alopecia universalis, and alopecia totalis after dupilumab treatment for AD. We present one of the few reported cases that showed improvement of underlying alopecia universalis treated with dupilumab.

引用

页数：10

共 9 条

[1] Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci [J].

Betz, Regina C. ;

Petukhova, Lynn ;

Ripke, Stephan ;

Huang, Hailiang ;

Menelaou, Androniki ;

Redler, Silke ;

Becker, Tim ;

Heilmann, Stefanie ;

Yamany, Tarek ;

Duvic, Madeliene ;

Hordinsky, Maria ;

Norris, David ;

Price, Vera H. ;

Mackay-Wiggan, Julian ;

de Jong, Annemieke ;

DeStefano, Gina M. ;

Moebus, Susanne ;

Boehm, Markus ;

Blume-Peytavi, Ulrike ;

Wolff, Hans ;

Lutz, Gerhard ;

Kruse, Roland ;

Bian, Li ;

Amos, Christopher I. ;

Lee, Annette ;

Gregersen, Peter K. ;

Blaumeiser, Bettina ;

Altshuler, David ;

Clynes, Raphael ;

de Bakker, Paul I. W. ;

Noethen, Markus M. ;

Daly, Mark J. ;

Christiano, Angela M. .

NATURE COMMUNICATIONS, 2015, 6

[2] Effectiveness of Dupilumab in the treatment of both atopic dermatitis and alopecia universalis [J].

Call, John E. ;

Sahni, Sakshi ;

Zug, Kathryn A. .

CLINICAL CASE REPORTS, 2020, 8 (08) :1337-1339

[3]

Gruenstein Diana, 2020, JAAD Case Rep, V6, P1286, DOI 10.1016/j.jdcr.2020.10.010

[4] Cytokine modulation of atopic dermatitis filaggrin skin expression (Reprinted from J Allergy Clin Immunol vol 120, pg 150-5, 2007) [J].

Howell, Michael D. ;

Kim, Byung Eui ;

Gao, Peisong ;

Grant, Audrey V. ;

Boguniewicz, Mark ;

DeBenedetto, Anna ;

Schneider, Lynda ;

Beck, Lisa A. ;

Barnes, Kathleen C. ;

Leung, Donald Y. M. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (03) :R7-R12

[5] Flow cytometric analysis of IL-4, IL-13 and IFN-γ expression in peripheral blood mononuclear cells and detection of circulating IL-13 in patients with atopic dermatitis provide evidence for the involvement of type 2 cytokines in the disease [J].

Kaminishi, K ;

Soma, Y ;

Kawa, Y ;

Mizoguchi, M .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2002, 29 (01) :19-25

[6] Dupilumab for treatment of atopic dermatitis [J].

Seegraeber, Marlene ;

Srour, Jerome ;

Walter, Alexandra ;

Knop, Macarena ;

Wollenberg, Andreas .

EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2018, 11 (05) :467-474

[7] Alopecia areata development in atopic dermatitis patients treated with dupilumab [J].

Staender, S. ;

Trense, Y. ;

Thaci, D. ;

Ludwig, R. J. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, 34 (10) :E612-E613

[8] Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing [J].

Suarez-Farinas, Mayte ;

Ungar, Benjamin ;

Noda, Shinji ;

Shroff, Anjali ;

Mansouri, Yasaman ;

Fuentes-Duculan, Judilyn ;

Czernik, Annette ;

Zheng, Xiuzhong ;

Estrada, Yeriel D. ;

Xu, Hui ;

Peng, Xiangyu ;

Shemer, Avner ;

Krueger, James G. ;

Lebwohl, Mark G. ;

Guttman-Yassky, Emma .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 136 (05) :1277-1287

[9] Viral infections in atopic dermatitis: Pathogenic aspects and clinical management [J].

Wollenberg, A ;

Wetzel, S ;

Burgdorf, WHC ;

Haas, J .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 112 (04) :667-674

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