Prenylated flavonoids as tyrosinase inhibitors

被引：51

作者：

Lee, NK

Son, KH

Chang, HW

Kang, SS

Park, H

Heo, MY

Kim, HP ^{[1
]}

机构：

[1] Kangwon Natl Univ, Coll Pharm, Chunchon 200701, South Korea

[2] Andong Natl Univ, Dept Food Nutr, Andong 760749, South Korea

[3] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[4] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 11期

关键词：

flavonoid; tyrosinase; skin; sanggenon; kuwanon; prenylation;

D O I：

10.1007/BF02975118

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable inhibitory activity. Especially, sanggenon D is revealed as a potent inhibitor (IC50 = 7.3 muM), compared to the reference compound, kojic acid (IC50 = 24.8 muM). However, the prenylation with isoprenyl group or the vinylation to flavonoid molecules did not enhance tyrosinase inhibitory activity.

引用

页码：1132 / 1135

页数：4

共 16 条

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