Fabrication of core or shell reversibly photo cross-linked micelles and nanogels from double responsive water-soluble block copolymers

被引：76
作者：
Jin, Qiao [1 ]
Liu, Xiangsheng [1 ]
Liu, Gongyan [1 ]
Ji, Jian [1 ]
机构：
[1] Zhejiang Univ, Minst Educ, Dept Polymer Sci, Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China
来源：
POLYMER | 2010年 / 51卷 / 06期
关键词：
Photo cross-linking; Nanogel; Micelle; TRIBLOCK COPOLYMERS; MICELLIZATION; STABILIZATION; TEMPERATURE; BEHAVIOR; LINKING;
D O I：
10.1016/j.polymer.2010.01.026
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Poly(butanechoic acid, 1-[3-[(2-methyl-1-oxo-2-propen-1-yl)oxy]propy]) ester)-b-poly(methoxydi(ethylene glycol) methacrylate-co-4-methyl-[7-(methacryloyl)oxyethyloxy] coumarin) (PSPMA-b-P(DEGMMA-co-CMA)) block copolymer was synthesized via atom transfer radical polymerization (ATRP) The temperature and pH responsive micellization behaviors of PSPMA-b-P( DEGMMA-co-CMA) were investigated to obtain P(DEGMMA-co-CMA)-core and PSPMA-core micelles. After the two types of micelles were exposed to 365 nm UV light, core cross-linked (CCL) micelles and shell cross-linked (SCL) micelles were facilely prepared The photo cross-linking was proved to be reversibly controlled under alternative irradiation of 365 nm and 254 nm UV light More interestingly, block copolymer nanogels were fabricated by translating the hydrophobic core of the CCL and SCL micelles into hydrophilic via adjusting the temperature and pH. The sizes of the block copolymer nanogels can be facilely controlled by UV light irradiation The introduction of reversibly photo cross-linkable groups into the double responsive block copolymers provides a novel approach to develop more sophisticated, controllable, and smarter nanocarriers that might have great potentials in biomedical applications (C) 2010 Elsevier Ltd. All rights reserved
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页码：1311 / 1319
页数：9
相关论文
共 46 条
[1]  
Andrew BL, 2007, PROG POLYM SCI, V32, P283
[2]   Switching the inside and the outside of aggregates of water-soluble block copolymers with double thermoresponsivity [J].
Arotçaréna, M ;
Heise, B ;
Ishaya, S ;
Laschewsky, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (14) :3787-3793
[3]   Decoration of shell cross-linked reverse polymer micelles using ATRP: A new route to stimuli-responsive nanoparticles [J].
Babin, Jerome ;
Lepage, Martin ;
Zhao, Yue .
MACROMOLECULES, 2008, 41 (04) :1246-1253
[4]   Synthesis of near-monodisperse acidic homopolymers and block copolymers from hydroxylated methacrylic copolymers using succinic anhydride under mild conditions [J].
Bories-Azeau, X ;
Mérian, T ;
Weaver, JVM ;
Armes, SP ;
van den Haak, HJW .
MACROMOLECULES, 2004, 37 (24) :8903-8910
[5]   Facile synthesis of zwitterionic diblock copolymers without protecting group chemistry [J].
Bories-Azeau, X ;
Armes, SP ;
van den Haak, HJW .
MACROMOLECULES, 2004, 37 (07) :2348-2352
[6]   Synthesis of shell cross-linked micelles with tunable hydrophilic/hydrophobic cores [J].
Bütün, V ;
Billingham, NC ;
Armes, SP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (46) :12135-12136
[7]   Synthesis and characterization of novel "schizophrenic" water-soluble triblock copolymers and shell cross-linked micelles [J].
Bütün, V ;
Top, RB ;
Ufuklar, S .
MACROMOLECULES, 2006, 39 (03) :1216-1225
[8]   A brief review of 'schizophrenic' block copolymers [J].
Butun, V ;
Liu, S ;
Weaver, JVM ;
Bories-Azeau, X ;
Cai, Y ;
Armes, SP .
REACTIVE & FUNCTIONAL POLYMERS, 2006, 66 (01) :157-165
[9]   Unusual aggregation behavior of a novel tertiary amine methacrylate-based diblock copolymer: Formation of micelles and reverse micelles in aqueous solution [J].
Butun, V ;
Billingham, NC ;
Armes, SP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (45) :11818-11819
[10]   Micelles and 'reverse micelles' with a novel water-soluble diblock copolymer [J].
Butun, Vural ;
Sonmez, Sule ;
Yarligan, Selma ;
Taktak, Fadime Fulya ;
Atay, Ahmet ;
Butun, Sultan .
POLYMER, 2008, 49 (19) :4057-4065
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