Regulatory Role of Circular RNAs and Neurological Disorders

被引：189
作者：
Floris, Gabriele [1 ]
Zhang, Longbin [3 ]
Follesa, Paolo [4 ]
Sun, Tao [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai 200240, Peoples R China
[2] Cornell Univ, Dept Cell & Dev Biol, Weill Med Coll, 1300 York Ave,Box 60, New York, NY 10065 USA
[3] Huaqiao Univ, Quanzhou 362021, Peoples R China
[4] Univ Cagliari, Dept Life & Environm Sci, Cagliari, Italy
来源：
MOLECULAR NEUROBIOLOGY | 2017年 / 54卷 / 07期
基金：
美国国家科学基金会;
关键词：
Circular RNA; Back-splicing; Regulatory RNA; microRNA sponge; Neurodegeneration; CIRCRNA BIOGENESIS; ABUNDANT; REVEALS; EFFICIENT; TRANSCRIPTION; TRANSLATION; EXPRESSION; DISEASE; GROWTH; BRAIN;
D O I：
10.1007/s12035-016-0055-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Circular RNAs (circRNAs) are a class of long noncoding RNAs that are characterized by the presence of covalently linked ends and have been found in all life kingdoms. Exciting studies in regulatory roles of circRNAs are emerging. Here, we summarize classification, characteristics, biogenesis, and regulatory functions of circRNAs. CircRNAs are found to be preferentially expressed along neural genes and in neural tissues. We thus highlight the association of circRNA dysregulation with neurodegenerative diseases such as Alzheimer's disease. Investigation of regulatory role of circRNAs will shed novel light in gene expression mechanisms during development and under disease conditions and may identify circRNAs as new biomarkers for aging and neurodegenerative disorders.
引用
收藏
页码：5156 / 5165
页数：10
相关论文
共 58 条
[1]   Circular RNAs in monkey muscle: age-dependent changes [J].
Abdelmohsen, Kotb ;
Panda, Amaresh C. ;
De, Supriyo ;
Grammatikakis, Ioannis ;
Kim, Jiyoung ;
Ding, Jun ;
Noh, Ji Heon ;
Kim, Kyoung Mi ;
Mattison, Julie A. ;
de Cabo, Rafael ;
Gorospe, Myriam .
AGING-US, 2015, 7 (11) :903-910
[2]   Rolling Circle Translation of Circular RNA in Living Human Cells [J].
Abe, Naoko ;
Matsumoto, Ken ;
Nishihara, Mizuki ;
Nakano, Yukiko ;
Shibata, Aya ;
Maruyama, Hideto ;
Shuto, Satoshi ;
Matsuda, Akira ;
Yoshida, Minoru ;
Ito, Yoshihiro ;
Abe, Hiroshi .
SCIENTIFIC REPORTS, 2015, 5
[3]   Rolling Circle Amplification in a Prokaryotic Translation System Using Small Circular RNA [J].
Abe, Naoko ;
Hiroshima, Michio ;
Maruyama, Hideto ;
Nakashima, Yuko ;
Nakano, Yukiko ;
Matsuda, Akira ;
Sako, Yasushi ;
Ito, Yoshihiro ;
Abe, Hiroshi .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (27) :7004-7008
[4]   Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models [J].
Armakola, Maria ;
Higgins, Matthew J. ;
Figley, Matthew D. ;
Barmada, Sami J. ;
Scarborough, Emily A. ;
Diaz, Zamia ;
Fang, Xiaodong ;
Shorter, James ;
Krogan, Nevan J. ;
Finkbeiner, Steven ;
Farese, Robert V., Jr. ;
Gitler, Aaron D. .
NATURE GENETICS, 2012, 44 (12) :1302-1309
[5]   circRNA Biogenesis Competes with Pre-mRNA Splicing [J].
Ashwal-Fluss, Reut ;
Meyer, Markus ;
Pamudurti, Nagarjuna Reddy ;
Ivanov, Andranik ;
Bartok, Osnat ;
Hanan, Mor ;
Evantal, Naveh ;
Memczak, Sebastian ;
Rajewsky, Nikolaus ;
Kadener, Sebastian .
MOLECULAR CELL, 2014, 56 (01) :55-66
[6]   Circular RNA biogenesis can proceed through an exon-containing lariat precursor [J].
Barrett, Steven P. ;
Wang, Peter L. ;
Salzman, Julia .
ELIFE, 2015, 4 :1-18
[7]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
[8]   CIRCULAR TRANSCRIPTS OF THE TESTIS-DETERMINING GENE SRY IN ADULT-MOUSE TESTIS [J].
CAPEL, B ;
SWAIN, A ;
NICOLIS, S ;
HACKER, A ;
WALTER, M ;
KOOPMAN, P ;
GOODFELLOW, P ;
LOVELLBADGE, R .
CELL, 1993, 73 (05) :1019-1030
[9]   The mouse formin (Fmn) gene: Abundant circular RNA transcripts and gene-targeted deletion analysis [J].
Chao, CW ;
Chan, DC ;
Kuo, A ;
Leder, P .
MOLECULAR MEDICINE, 1998, 4 (09) :614-628
[10]   INITIATION OF PROTEIN-SYNTHESIS BY THE EUKARYOTIC TRANSLATIONAL APPARATUS ON CIRCULAR RNAS [J].
CHEN, CY ;
SARNOW, P .
SCIENCE, 1995, 268 (5209) :415-417
123456