Regulatory Role of Circular RNAs and Neurological Disorders

被引：181

作者：

Floris, Gabriele ^{[1
]}

Zhang, Longbin ^{[3
]}

Follesa, Paolo ^{[4
]}

Sun, Tao ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai 200240, Peoples R China

[2] Cornell Univ, Dept Cell & Dev Biol, Weill Med Coll, 1300 York Ave,Box 60, New York, NY 10065 USA

[3] Huaqiao Univ, Quanzhou 362021, Peoples R China

[4] Univ Cagliari, Dept Life & Environm Sci, Cagliari, Italy

来源：

MOLECULAR NEUROBIOLOGY | 2017年 / 54卷 / 07期

基金：

美国国家科学基金会;

关键词：

Circular RNA; Back-splicing; Regulatory RNA; microRNA sponge; Neurodegeneration; CIRCRNA BIOGENESIS; ABUNDANT; REVEALS; EFFICIENT; TRANSCRIPTION; TRANSLATION; EXPRESSION; DISEASE; GROWTH; BRAIN;

D O I：

10.1007/s12035-016-0055-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Circular RNAs (circRNAs) are a class of long noncoding RNAs that are characterized by the presence of covalently linked ends and have been found in all life kingdoms. Exciting studies in regulatory roles of circRNAs are emerging. Here, we summarize classification, characteristics, biogenesis, and regulatory functions of circRNAs. CircRNAs are found to be preferentially expressed along neural genes and in neural tissues. We thus highlight the association of circRNA dysregulation with neurodegenerative diseases such as Alzheimer's disease. Investigation of regulatory role of circRNAs will shed novel light in gene expression mechanisms during development and under disease conditions and may identify circRNAs as new biomarkers for aging and neurodegenerative disorders.

引用

页码：5156 / 5165

页数：10

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