Practical synthesis of alpha-(trifluoromethyl)phenylacetic acid

被引：11

作者：

Nemeth, G ^{[1
]}

Rakoczy, E ^{[1
]}

Simig, G ^{[1
]}

机构：

[1] EGIS PHARMACEUT LTD,DIV CHEM RES,H-1475 BUDAPEST,HUNGARY

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1996年 / 76卷 / 01期

关键词：

alpha-(trifluoromethyl)phenylacetic acid derivatives; mesylates; catalytic hydrogenation; NMR spectroscopy; IR spectroscopy;

D O I：

10.1016/0022-1139(95)03338-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

alpha-(Trifluoromethyl)phenylacetic acid (1) was synthesized in good overall yield starting from the cyanohydrin of alpha,alpha,alpha-trifluoroacetophenone, via hydrogenolysis of alpha-mesyloxy-alpha-(trifluoromethyl)phenylacetamide or ethyl alpha-mesyloxy-alpha-(trifluoromethyl)phenylacetate followed by acidic hydrolysis.

引用

页码：91 / 93

页数：3

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