Zinc enzyme modelling with zinc complexes of polar pyrazolylborate ligands

被引：11

作者：

Olmo, C. Perez ^{[1
]}

Boehmerle, K. ^{[1
]}

Vahrenkamp, H. ^{[1
]}

机构：

[1] Univ Freiburg, Inst Anorgan & Analyt Chem, D-79104 Freiburg, Germany

来源：

INORGANICA CHIMICA ACTA | 2007年 / 360卷 / 05期

关键词：

bioinorganic chemistry; CO2; activation; ester cleavage; pyrazolylborate ligands; zinc; PHOSPHATE ESTER CLEAVAGE; HYDROXIDE COMPLEXES; SYNTHETIC ANALOGS; CRYSTAL-STRUCTURE; HYDROLYSIS; CHEMISTRY; DONORS; ION;

D O I：

10.1016/j.ica.2006.08.021

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The Zn-OH2, and Zn-OH complexes of the new tris(pyrazolyl)borate ligands with pyridyl and carboxamido substituents were investigated for their reactivity towards hydrolyzeable substrates. Tp(4-Py,Me)Zn-OH inserted CO2 and CS2 in methanol forming the Zn-OCO-OMe and Zn-SCSOMe products. In non-aqueous media, both types of complexes with both types of substituents on the Tp ligands effected stoichiometric cleavage of tris(p-nitrophenyl)phosphate and p-nitrophenyl acetate. In solutions containing water and the MOPS buffer, up to eight p-nitrophenyl groups per equivalent of zinc complex could be cleaved from the esters, and the resulting bis(p-nitrophenyl)phosphate was also degraded to mono(p-nitrophenyl)phosphate. This is the first time that pyrazolylborate-zinc complexes have shown catalytic activity in hydrolytic reactions. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1510 / 1516

页数：7

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