Recombinant human granulocyte-macrophage colony-stimulating factor as treatment for chronic leg ulcers

被引：0

作者：

Borbolla-Escoboza, JR ^{[1
]}

Maria-Aceves, R ^{[1
]}

Lopez-Hernandez, MA ^{[1
]}

Collados-Larumbe, MT ^{[1
]}

机构：

[1] Ctr Med Nacl 20 Noviembre, Serv Hematol, Mexico City 14090, DF, Mexico

来源：

REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION | 1997年 / 49卷 / 06期

关键词：

chronic leg ulcers; GM-CSF;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the safety and effectiveness of a single subcutaneous perilesional administration of 300 mu g of recombinant human granulocyte-macrophage colony stimulating factor (rHGM-CSF) for the treatment of chronic leg ulcers. Design. Prospective, descriptive evaluation in an outpatient group. Setting. The Centro Medico Nacional 20 de Noviembre, ISSSTE, Mexico City. Patients. 10 patients with chronic leg ulcers. Measurements. Ulcer diameter and side effects. Results. After 4 weeks observation, 8 of the 10 ulcers had healed; the other two had a mean diameter decrease of 21%. The only side effect was found in a 58 year old female who complained of moderate perilesional pain two days after having received treatment: it was successfully treated with paracetamol. Conclusion. We believe that a single perilesional subcutaneous administration of rhGM-CSF is safe and effective for the treatment of chronic leg ulcers.

引用

页码：449 / 451

页数：3

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